Toxic effect of essential oils (Copaifera spp) in the treatment of mice experimentally infected with Trypanosoma evansi

Biomedicine & Preventive Nutrition Pub Date : 2014-04-01 DOI:10.1016/j.bionut.2014.03.001

Matheus D. Baldissera , Camila B. Oliveira , Alexandre A. Tonin , Patricia Wolkmer , Sonia T.A. Lopes , Rafael Fighera , Mariana M. Flores , Elaine C.P. Oliveira , Roberto C.V. Santos , Aline A. Boligon , Margareth L. Athayde , Silvia G. Monteiro , Aleksandro S. Da Silva

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引用次数: 5

Abstract

The aims of this study were to test the effectiveness of copaiba essential oils controlling trypanosomosis and to describe the toxic effect of copaiba essential oil used in treatment of mice infected with Trypanosoma evansi. The experiment was designed, testing the effect of three different oils of copaiba species (Copaifera reticulata, Copaifera paupera and Copaifera duckei) in the mice in dose 1.0 mL kg⁻¹ during 3 days. However, they did not reach the curative efficacy, showing that only C. paupera oil was able to prolong the survival of mice. The three tested oils were toxic at the used doses to the mice due to the verification of increased levels of alanine aminotransferase, alkaline phosphatase, lipid peroxidation and observation of histopathological lesions in liver. The curative effect was not observed; being only able to prolong the lifespan of the animals treated with oil of copaiba, as well as the dose of oils was toxic to animals.

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精油对伊氏锥虫实验感染小鼠的毒性作用

本研究的目的是测试可伐巴精油控制锥虫病的有效性，并描述可伐巴精油用于治疗小鼠感染埃氏锥虫的毒性作用。本实验设计了三种不同种类的Copaifera (Copaifera reticulata, Copaifera paupera, Copaifera duckei)精油，以1.0 mL kg−1的剂量连续3天对小鼠的影响。但并没有达到疗效，说明只有苦瓜油能够延长小鼠的生存期。经验证，三种油在使用剂量下对小鼠有毒性，其丙氨酸转氨酶、碱性磷酸酶、脂质过氧化水平升高，并观察肝脏组织病理学病变。未观察疗效;只能延长用copaiba油治疗过的动物的寿命，而且油的剂量对动物是有毒的。

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Biomedicine & Preventive Nutrition

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