{"title":"Gasdermins and their role in immunity and inflammation","authors":"Pontus Orning, E. Lien, K. Fitzgerald","doi":"10.1084/jem.20190545","DOIUrl":null,"url":null,"abstract":"Pyroptosis is an important component of the innate immune system. Gasdermin D, the mediator of pyroptosis, has been shown to be crucial for optimal defense against microbial infection. In this review, the authors discuss gasdermin D and its role in disease.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"15 1","pages":"2453 - 2465"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"169","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190545","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 169
Abstract
Pyroptosis is an important component of the innate immune system. Gasdermin D, the mediator of pyroptosis, has been shown to be crucial for optimal defense against microbial infection. In this review, the authors discuss gasdermin D and its role in disease.
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