Chihiro Kurematsu, Masato Sawada, M. Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, M. Matsumoto, Hisashi Oishi, H. Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, T. Q. Thai, S. Kohsaka, N. Ohno, M. Yamada, Masato Asai, M. Sokabe, J. Nabekura, K. Asano, Masato Tanaka, K. Sawamoto
{"title":"Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine","authors":"Chihiro Kurematsu, Masato Sawada, M. Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, M. Matsumoto, Hisashi Oishi, H. Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, T. Q. Thai, S. Kohsaka, N. Ohno, M. Yamada, Masato Asai, M. Sokabe, J. Nabekura, K. Asano, Masato Tanaka, K. Sawamoto","doi":"10.1084/jem.20202304","DOIUrl":null,"url":null,"abstract":"Mechanisms for synaptic pruning of adult-born neurons remain unknown. In this study, Kurematsu et al. demonstrate that phosphatidylserine is involved in microglial spine pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"85 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20202304","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
Abstract
Mechanisms for synaptic pruning of adult-born neurons remain unknown. In this study, Kurematsu et al. demonstrate that phosphatidylserine is involved in microglial spine pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus.