Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar-Based Amphipathic Compounds

Z. Xin, Binbin Du, Yanming Wang, Shengxu Qian, Weijia Li, Yuan Gao, Miao Sun, Shifang Luan, Jinghua Yin
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引用次数: 2

Abstract

Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft polymerization was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing polymer surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased.
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表面接枝糖基两亲性化合物聚氨酯膜的血液相容性评价
成功制备了糖基两亲性化合物(BA-CnAG)。采用紫外辐照法接枝甲基丙烯酸缩水甘油酯(GMA),并根据环氧基开环的特点,用BA-CnAG对聚氨酯(PU)进行改性。ATR-FTIR和XPS证实了表面接枝聚合反应。采用水接触角、蛋白质吸附和血小板粘附测量来评价膜的亲水性和血液相容性。结果表明,BA-CnAG功能化后,含两亲性表面活性剂的聚合物表面具有抗蛋白和抗血小板粘附的行为。此外,改性后表面的血液相容性随着BA-CnAG疏水链长度的增加而恶化。
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