Efficiency of lycopene against reproductive and developmental toxicity of Bisphenol A in male Sprague Dawley rats

Abstract

Bisphenol A (BPA) is an estrogenic environmental toxicant and it is a globally used endocrine disruptor that is incorporated in many plastic industries. The revelation BPA has been implicated to have perilous consequences on reproductive healthiness in human and experimental animals. Present examination endeavor to appraise a powerful antioxidant lycopene against an estrogenic compound BPA. Healthy adult male Sprague Dawley rats were subjected to Bisphenol A (200 mg/kg body weight) dissolved in corn oil (1 mL) administered orally for 30 days. The pathological alterations due to BPA encouraged oxidative stress were evaluated in testis and epidydimis tissues. Simultaneously, adjustments in testicular hormones, sperm characteristic, biological enzymes like antioxidant enzymes, elevated peroxide reactions and enhanced ROS formations were measured in reproductive toxicity rats. Captivatingly, oral administration of lycopene (10 mg/kg body weight) with BPA intoxicated rats reduced the testicular toxic condition, biochemical and morphological changes were brought back to normal. In termination, antioxidant potential of lycopene, ameliorates the changes that are induced by BPA.