Quantitative determination of Trazodoe hydrochloride in bulk and pharmaceutical dosage form by Zero order and AUC by UV-spectrophotometry

Abstract

Two simple UV-Spectrophotometric methods have been developed for estimation of trazodone HCl (TZH) in bulk and pharmaceutical formulation form by using Zero order UV spectrometric absorbance method (method I) and Zero order UV spectrometric method using area under curve technique (method II). Water was used as solvent. In these Method λ max was found to be 246.0 nm of TZH and AUC between two wavelengths 235.20 nm – 256.60 nm. In both method Linearity in the concentration range of 05-35 μg/ml (r2>0.99)for TZH. Proposed methods were applied for oral dosage and amounts of TZH estimated by method I were found to be 99, by Method II were found to be 98.80 respectively. Both these methods were validated statistically and by recovery experiments. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)