Rémy Rodriguez, B. Fournier, D. J. Cordeiro, Sarah Winter, K. Izawa, Emmanuel Martin, D. Boutboul, C. Lenoir, S. Fraitag, S. Kracker, T. Watts, C. Picard, J. Bruneau, I. Callebaut, A. Fischer, B. Neven, S. Latour
{"title":"Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells","authors":"Rémy Rodriguez, B. Fournier, D. J. Cordeiro, Sarah Winter, K. Izawa, Emmanuel Martin, D. Boutboul, C. Lenoir, S. Fraitag, S. Kracker, T. Watts, C. Picard, J. Bruneau, I. Callebaut, A. Fischer, B. Neven, S. Latour","doi":"10.1084/jem.20190678","DOIUrl":null,"url":null,"abstract":"Identification of biallelic loss-of-function mutations in TNFRSF9 and PIK3CD in a kindred with chronic active Epstein-Barr virus infection of T cells (CAEBV) suggests that CAEBV is the consequence of factors providing growth advantage to EBV-infected T cells combined with defective cell immunity toward EBV-infected cells.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"75 1","pages":"2800 - 2818"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"50","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190678","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 50
Abstract
Identification of biallelic loss-of-function mutations in TNFRSF9 and PIK3CD in a kindred with chronic active Epstein-Barr virus infection of T cells (CAEBV) suggests that CAEBV is the consequence of factors providing growth advantage to EBV-infected T cells combined with defective cell immunity toward EBV-infected cells.
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