A 2D Transient Computational Multi-Physics Model for Analyzing Magnetic and Non-Magnetic Particle (Red Blood Cells and E. Coli bacteria) Dynamics in a Travelling Wave Ferro-Magnetic Microfluidic Device for Potential Cell Separation and Sorting

Rodward L. Hewlin, Maegan Edwards, Michael Smith
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引用次数: 5

Abstract

This paper presents the theory and development, validation, and results of a transient computational multi-physics model for analyzing the magnetic field, particle dynamics, and capture efficiency of magnetic and non-magnetic (e.g., Red Blood Cells and E. Coli bacteria) microparticles in a travelling wave ferro-magnetic microfluidic device. This computational model demonstrates proof-of-concept of a method for greatly enhancing magnetic bio-separation in ferro-microfluidic systems using an array of copper conductive elements arranged in quadrature to create a periodic potential energy landscape. In contrast to previous works, our approach theoretically uses a microfluidic device with an electronic chip platform consisting of integrated copper electrodes that carry currents to generate programmable magnetic field gradients locally. Alternating currents are applied to the electrodes in quadrature (using a 90° phase change from the neighboring electrode) to create a periodic magnetic field pattern that travels along the length of the microchannel. Our previous work evaluated magnetic and non-magnetic particles in a static magnetic field within the same channel geometry. This work is a phase 2 study that expands on the previous work and analyzes the dynamics of magnetic and non-magnetic entities characterized by material magnetic susceptibility in a transient magnetic field. This is an improvement over our previous work. The model, which is described in more detail in the methods section, combines a Eulerian-Lagrangian and two-way particle-fluid coupling CFD analysis with closed-form magnetic field analysis that is used to predict magnetic separation considering dominant magnetic and hydrodynamic forces similar to our previous works in magnetic drug targeting. The model was also validated with an experimental low frequency stationary flow study on separating non-magnetic latex fluorescent particles in a water based ferrofluid. The results from the experimental study and the developed model demonstrates that the proposed device may potentially be used as an effective platform for microparticle and cellular manipulation and sorting. The developed multi-physics model could potentially be used as a design optimization tool for traveling wave ferro-microfluidic devices.
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在行波铁磁微流控装置中分析磁性和非磁性粒子(红细胞和大肠杆菌)动力学的二维瞬态计算多物理模型
本文介绍了一种瞬态计算多物理模型的理论、发展、验证和结果,该模型用于分析行波铁磁微流控装置中磁性和非磁性(如红细胞和大肠杆菌)微粒子的磁场、粒子动力学和捕获效率。该计算模型证明了一种方法的概念验证,该方法可以极大地增强铁微流体系统中的磁性生物分离,该方法使用一组铜导电元件以正交方式排列以创建周期性势能景观。与以前的工作相比,我们的方法在理论上使用了一个带有电子芯片平台的微流体装置,该电子芯片平台由集成的铜电极组成,该电极携带电流,以在局部产生可编程的磁场梯度。交流电被施加到正交电极上(使用来自相邻电极的90°相位变化),以产生沿微通道长度传播的周期性磁场图案。我们之前的工作评估了在相同通道几何形状的静态磁场中的磁性和非磁性颗粒。本工作是第二阶段的研究,扩展了之前的工作,并分析了瞬变磁场中以材料磁化率为特征的磁性和非磁性实体的动力学。这比我们以前的工作有了改进。该模型将欧拉-拉格朗日和双向粒子-流体耦合CFD分析与封闭形式的磁场分析相结合,考虑主导磁力和流体动力,用于预测磁分离,类似于我们之前在磁性药物靶向方面的工作。该模型还通过在水基铁磁流体中分离非磁性乳胶荧光颗粒的实验低频稳态流动研究进行了验证。实验研究和开发的模型的结果表明,所提出的设备可能被用作微粒和细胞操作和分类的有效平台。所建立的多物理场模型可作为行波铁磁微流控器件的优化设计工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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