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High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts. 高速三维数字图像相关性和 Schlieren 图像与冲击管加载相结合,用于研究暴露于爆炸物的人体鼓膜的动态响应。
Pub Date : 2025-11-01 Epub Date: 2024-10-23 DOI: 10.1115/1.4066622
Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng

Investigating the dynamic response of human tympanic membranes (TMs) exposed to blasts requires full-field-of-view and three-dimensional (3D) methodologies. Our paper introduces a system that combines high-speed 3D digital image correlation (HS 3D-DIC) and Schlieren imaging (HS-SI) with a custom-designed shock tube for generating blast waves. This integrated system allows us to measure TM surface motions under intense transient loading, capturing full-field-of-view shape deformations exceeding 100 μm with a temporal resolution of 10 μs. System characterization encompasses (i) measuring the shock tube's output levels and repeatability, (ii) assessment of the spatial and temporal resolutions of the imaging techniques, and (iii) identification of overall system limitations. Optimizing these factors is crucial for improving the reliability of our system to ensure the accurate measurement of deformations. To assess our shock tube's reliability in generating repeated blast waves, we instrumented it with high-pressure (HP) and high-frequency (HF) pressure sensors along the blast wave pathway to record overpressure waveforms and compared them with Schlieren imaging visualized blast waves. We validate our HS 3D-DIC measured deformations by comparing them with deformations measured using single-point laser Doppler vibrometry (LDV), establishing a comprehensive assessment of the TM's dynamic response and potential fracture mechanics under blast. Finally, we test our approach with 3D-printed TM-like samples and a real cadaveric human TM. This methodology lays the groundwork for further investigations of blast-related auditory damage and the invention of more effective protective and medical solutions.

研究人体鼓膜(TM)暴露于爆炸物时的动态反应需要全视场和三维(3D)方法。我们的论文介绍了一种将高速三维数字图像相关性(HS 3D-DIC )和 Schlieren 成像(HS-SI)与用于产生爆炸波的定制设计的冲击管相结合的系统。这种集成系统使我们能够测量强烈瞬态加载下的 TM 表面运动,捕捉超过 100 μm 的全视场形状变形,时间分辨率为 10 μs。系统鉴定包括:(i) 测量冲击管的输出水平和可重复性;(ii) 评估成像技术的空间和时间分辨率;(iii) 确定整个系统的局限性。优化这些因素对于提高我们系统的可靠性以确保精确测量变形至关重要。为了评估冲击管在产生重复冲击波时的可靠性,我们在冲击波路径上安装了高压(HP)和高频(HF)压力传感器,以记录超压波形,并将其与 Schlieren 成像可视化冲击波进行比较。我们将 HS 3D-DIC 测量的变形与单点激光多普勒测振仪 (LDV) 测量的变形进行比较,从而验证我们的 HS 3D-DIC 测量变形,建立了对爆破下 TM 动态响应和潜在断裂力学的全面评估。最后,我们用 3D 打印的 TM 样品和真实的人体尸体 TM 对我们的方法进行了测试。这种方法为进一步研究与爆炸相关的听觉损伤以及发明更有效的保护和医疗解决方案奠定了基础。
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引用次数: 0
Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography. 利用弥散磁共振成像和韧带造影术量化跟腱康复患者的筋膜变化
Pub Date : 2025-08-01 Epub Date: 2024-10-16 DOI: 10.1115/1.4066623
Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes

Regardless of the way of treatment, persistent deficits in calf muscles in recovered patients from Achilles tendon rupture (ATR) exist long-term postinjury. Studies on calf muscle changes mostly highlight morphological changes in the calf muscles and Achilles tendon. However, limited attention has been given to fascicular changes. Diffusion tensor imaging (DTI) can provide a better understanding of the characteristics and properties of tissues with organized microstructure. In the current study, we used DTI-derived indices (mean diffusivity (MD), fractional anisotropy (FA), and eigenvalues-λ 1, λ 2, and λ 3) and fiber tractography to better understand the soleus muscle after recovery from ATR by comparing the results of injured legs with healthy ones. Our findings suggest that the standard deviations of measured parameters (FA, MD, and eigenvalues) within the soleus muscle are better predictors of the changes associated with the ATR as compared to the control counterpart for the volumetric region of interest (ROI). Additionally, in four out of five participants, smaller tracts were observed in the injured leg compared to the healthy one, as evidenced by the fiber length distribution of the tracts. Altogether, this study demonstrates the feasibility of the DTI and fiber tractography approaches to quantify the fascicular changes in the individuals recovered from ATR.

无论采用何种治疗方法,跟腱断裂(ATR)康复者的小腿肌肉在伤后长期存在持续性缺陷。有关小腿肌肉变化的研究大多强调小腿肌肉和跟腱的形态变化。然而,人们对筋膜变化的关注有限。弥散张量成像(DTI)可以更好地了解具有组织微观结构的组织的特征和特性。在本研究中,我们使用了 DTI 衍生指数(平均扩散率 (MD)、分数各向异性 (FA)、特征值-λ 1、λ 2 和 λ 3)和纤维束成像,通过比较受伤腿和健康腿的结果,更好地了解比目鱼肌从 ATR 恢复后的情况。我们的研究结果表明,与对照组相比,比目鱼肌内测量参数(FA、MD 和特征值)的标准偏差能更好地预测与 ATR 相关的容积感兴趣区(ROI)的变化。此外,从纤维束的长度分布来看,在五名参与者中的四名,受伤腿部的纤维束比健康腿部的要小。总之,这项研究证明了用 DTI 和纤维束成像方法量化 ATR 康复者筋膜变化的可行性。
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引用次数: 0
Assistive Technology for Real-Time Fall Prevention during Walking: Evaluation of the Effect of an Intelligent Foot Orthosis 步行时实时预防跌倒的辅助技术:评估智能足部矫形器的效果
Pub Date : 2024-08-10 DOI: 10.1115/1.4066187
Rieko Yamamoto, S. Itami, Masashi Kawabata, Kohei Morimura, Toshihiko Shiraishi
We present an intelligent foot orthosis (IFO) designed to prevent lateral falls during walking by employing a magnetorheological (MR) fluid brake. This study aims to demonstrate the feasibility of evaluating the effectiveness of the proposed orthosis in fall prevention. Seventeen healthy adults underwent four conditions: (1) without IFO, (2) with IFO and current-OFF, (3) with IFO current-ON, and (4) with IFO and control-ON. Gait was assessed by three-dimensional motion capture and with ground reaction force. Postural changes on the frontal plane were measured, and the mediolateral center of gravity and center of pressure inclination angle (ML COG-COP IA) was calculated. Additionally, tibialis anterior (TA) and peroneus longus (PL) muscle activity during walking were measured using surface electromyography. Results indicate a significant increase in ML COG-COP IA in (3). No significant differences were found in muscle activity between conditions. The study suggests that the posture's deviation from the lateral fall direction in (3) is primarily due to wearing the IFO, emphasizing human postural control over muscle activity. A negative correlation between ML COG-COP IA and TA muscle activity under (4), implies that individuals with lower TA muscle activity may benefit more from IFO fall prevention. In conclusion, the study demonstrates the feasibility of preventing lateral falls in human walking using the proposed orthosis with an MR fluid brake. The general efficacy of the orthosis in lateral fall prevention is suggested, emphasizing the need for further development.
我们介绍了一种智能足部矫形器(IFO),其设计目的是通过采用磁流变(MR)流体制动器来防止行走过程中的侧向跌倒。本研究旨在证明评估该矫形器在预防跌倒方面的有效性的可行性。17 名健康成年人接受了四种情况的训练:(1) 无 IFO;(2) IFO 和电流-关;(3) IFO 电流-开;(4) IFO 和控制-开。步态通过三维运动捕捉和地面反作用力进行评估。测量了正面的姿势变化,并计算了内外侧重心和压力中心倾斜角(ML COG-COP IA)。此外,还使用表面肌电图测量了行走时胫骨前肌(TA)和腓肠肌(PL)的肌肉活动。结果表明,(3)的 ML COG-COP IA 明显增加。不同条件下的肌肉活动无明显差异。研究表明,(3)中姿势偏离侧向跌倒方向的主要原因是佩戴了 IFO,强调了人体姿势控制高于肌肉活动。在(4)中,ML COG-COP IA 与 TA 肌肉活动呈负相关,这意味着 TA 肌肉活动较低的个体可能会从 IFO 预防跌倒中获益更多。总之,这项研究证明了使用带有磁共振流体制动器的拟议矫形器预防人体行走时横向跌倒的可行性。该矫形器在预防侧向跌倒方面具有普遍功效,强调了进一步开发的必要性。
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引用次数: 0
A Simple Poc Device for Temperature Control of Multiple Reactions During Recombinase Polymerase Amplification 用于重组酶聚合酶扩增过程中多个反应温度控制的简单 Poc 装置
Pub Date : 2024-07-26 DOI: 10.1115/1.4066055
Aubrey Schultz, Shannon Servoss, Robert Beitle
For individuals with infectious diseases, early and accurate diagnosis is critical. A rapid diagnosis allows for prompt and effective treatment and increases the chance of a full recovery without complications. Additionally, when containing a wide-scale infectious disease outbreak, circumstances are significantly improved by the ability to test the populace frequently, swiftly, and affordably. Regarding specificity and sensitivity, nucleic acid amplification tests (NAAT) are one of the best options for diagnosing infectious diseases. Historically, polymerase chain reaction (PCR) has been used, but complex thermocycling and complicated PCR protocols have often limited PCR to clinical settings. Due to increased simplicity, the isothermal NAAT recombinase polymerase amplification (RPA) has the potential to deliver reliable POC diagnostics in low-resource settings. When designing POC devices for isothermal NAATs, creating isothermal temperature conditions is perhaps the most significant challenge. This work presents a flexible and robust device capable of incubating 3 RPA reactions for simultaneous amplification in conditions conducive to POC testing. The device costs ~$ 60 USD to construct and is easy to assemble. A battery-powered polyimide thin-film resistive heater provides energy, and the device only requires power for a fraction of the total incubation time. The device uses a phase change material (PCM) to regulate temperature to avoid the complexity of a microcontroller. RPA reactions were successfully incubated in 30 minutes using the device.
对于传染病患者来说,早期准确诊断至关重要。快速诊断可使治疗迅速而有效,并增加完全康复而无并发症的机会。此外,在控制大规模传染病爆发时,如果能够频繁、迅速、经济地对人群进行检测,情况就会大大改善。就特异性和灵敏度而言,核酸扩增检测(NAAT)是诊断传染病的最佳选择之一。聚合酶链反应(PCR)在历史上一直被使用,但复杂的热循环和复杂的 PCR 方案往往限制了 PCR 在临床环境中的应用。由于等温 NAAT 重组酶聚合酶扩增(RPA)更加简便,因此有可能在低资源环境中提供可靠的 POC 诊断。在为等温 NAAT 设计 POC 设备时,创造等温温度条件可能是最大的挑战。这项工作展示了一种灵活而坚固的设备,能够在有利于 POC 检测的条件下培养 3 个 RPA 反应,以同时进行扩增。该装置的建造成本约为 60 美元,易于组装。由电池供电的聚酰亚胺薄膜电阻加热器提供能量,该装置只需一小部分培养时间的电源。该装置使用相变材料(PCM)调节温度,避免了微控制器的复杂性。使用该装置在 30 分钟内成功培养了 RPA 反应。
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引用次数: 0
Auxetic Structure Inspired Microneedle Arrays for Minimally Invasive Drug Delivery 用于微创给药的磁性结构启发微针阵列
Pub Date : 2024-07-20 DOI: 10.1115/1.4066007
Maher Amer, Christina Fisher, Georgia Small, Blake Bullock, Vero Salinas, Jaden Langford
Microneedle Arrays (MNAs) are promising drug delivery tools aimed at lowering invasiveness and pain. Many design parameters are optimized to lower penetration force in MNAs. An important parameter is the microneedle width as that relates directly to the force required to penetrate the skin, the lower the width the lower the penetration force needed. This research explored the use of auxetic structures known for having negative Poisson ratios in the design of MNAs. As the needles are inserted the compression on the needles causes their radial dimension to shrink instead of increasing as in positive Poisson ration structures. This study has shown a 25% reduction in penetration force due to using an auxetic structure instead of a conventional non-auxetic structure. The research employs additive manufacturing and soft molding to fabricate the MNAs. This study emphasizes the viability of using auxetic structures in MNA design.
微针阵列(MNA)是一种很有前途的给药工具,旨在降低侵入性和疼痛。为了降低 MNA 的穿透力,对许多设计参数进行了优化。其中一个重要参数是微针宽度,因为它直接关系到穿透皮肤所需的力,宽度越小,所需的穿透力就越低。这项研究探索了在 MNA 设计中使用具有负泊松比的辅助结构。在插入针头时,针头受到的挤压会导致其径向尺寸缩小,而不是像正泊松比结构那样增大。这项研究表明,由于使用了辅助结构而不是传统的非辅助结构,穿刺力降低了 25%。研究采用了增材制造和软成型技术来制造 MNA。这项研究强调了在 MNA 设计中使用辅助结构的可行性。
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引用次数: 0
Hemodynamics of Circle of Willis Having Hypoplastic/Stenotic Anterior Cerebral Artery A1 Segment 大脑前动脉 A1 段发育不良/狭窄的威利斯环的血液动力学特征
Pub Date : 2024-07-20 DOI: 10.1115/1.4066008
Harikrishna M. Menon, Tondup Dolkar, Jayanand B Sudhir, Shine Sr
This study utilizes computational tools to analyze the hemodynamic effects of a hypoplastic/stenotic A1 segment in the Anterior Cerebral Artery (ACA) on the Circle of Willis (CoW). The objective is to investigate how variations in ACA A1 diameter affect flow dynamics, wall shear stress (WSS), and the initiation of aneurysms within the CoW. An idealized CoW geometry is employed, incorporating hypoplastic ACA A1 segments with reductions of 25%, 50%, 75%, and 100% in diameter and a 50% constriction representing stenosis. A 3D computational fluid dynamics (CFD) model explores flow dynamics and WSS distribution. The computational methodology is validated against experimental data from existing literature. The study demonstrates the resilience of overall brain perfusion despite a hypoplastic ACA A1 segment. Significant alterations and diversions in flow, particularly at the ACoM-ACA junction, are observed under varying degrees of hypoplasticity. Analysis of radial velocity profiles reveals asymmetry in flow distribution, exacerbating risks of arterial diseases such as atherosclerosis and thrombosis. Distinct patterns of WSS distribution during peak systole in the ACA A2 segment highlight the influence of hypoplasticity on vascular health, with implications for structural aberrations and aneurysm formation, particularly in the Posterior Cerebral Artery (PCA). A comparison study of rigid wall cases with elastic walls using a fluid-structure interaction (FSI) model is also done to understand the applicability of FSI. Insights gained from this research contribute to comprehending CoW anomalies' pathophysiology and offer guidance for developing effective treatment strategies.
本研究利用计算工具分析了大脑前动脉(ACA)中发育不良/狭窄的 A1 节段对威利斯环(CoW)的血流动力学影响。目的是研究 ACA A1 直径的变化如何影响血流动力学、管壁剪切应力(WSS)以及 CoW 内动脉瘤的形成。该研究采用了理想化的 CoW 几何结构,其中包括直径缩小 25%、50%、75% 和 100%的发育不良 ACA A1 区段,以及代表狭窄的 50%收缩。三维计算流体动力学(CFD)模型探讨了流动动力学和 WSS 分布。计算方法与现有文献中的实验数据进行了验证。研究结果表明,尽管 ACA A1 区段发育不良,但整体脑灌注仍具有恢复能力。在不同程度的发育不全情况下,都能观察到血流的显著变化和分流,尤其是在 ACoM-ACA 交界处。对径向流速剖面的分析显示,血流分布不对称,加剧了动脉粥样硬化和血栓形成等动脉疾病的风险。在 ACA A2 段的收缩峰值期间,WSS 分布的不同模式凸显了低塑性对血管健康的影响,并对结构畸变和动脉瘤的形成,尤其是大脑后动脉(PCA)的结构畸变和动脉瘤的形成产生了影响。此外,还利用流固耦合(FSI)模型对刚性壁和弹性壁进行了比较研究,以了解 FSI 的适用性。本研究获得的见解有助于理解CoW异常的病理生理学,并为制定有效的治疗策略提供指导。
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引用次数: 0
Reliability Test of Mobile Embedded Accelerometers and Gyroscopes with the Goal of Measuring Postural Stability for People with Parkinson's Disease 以测量帕金森病患者姿势稳定性为目标的移动嵌入式加速计和陀螺仪可靠性测试
Pub Date : 2024-07-01 DOI: 10.1115/1.4065860
Matthew Thelen, Alexis Meeker, Fardeen Mazumder, Mariam Tabbah, Linda Zhu, Charlotte Tang, Nathaniel S. Miller
Parkinson's Disease (PD) is the second most common neurodegenerative disease in the United States. The cardinal symptoms of PD are tremor, rigidity, slowed movement, and impaired balance. These symptoms often interfere with the daily activities of people with Parkinson's (PwPD) and negatively affect quality of life (QoL). Therefore, monitoring PD symptoms is essential for clinical evaluations and adjusting medication to help maintain QoL for PwPD. We are developing a mobile app to conduct at-home PD symptom monitoring to provide more timely, frequent, and accurate measurements of PD symptoms. While the tremor and finger-tapping results collected in the mobile app have been discussed in previous publications, this paper focuses on the design and evaluation of postural stability tests in the app and validating the reliability of the embedded accelerometers and gyroscopes in smartphones. During the test, a shaker was employed to provide vibration in amplitude and frequency ranges similar to human postural stability signals, and both the accelerometer and gyroscope measurements were evaluated. We used signal processing algorithms to extract postural stability factors, such as the root mean square (RMS) value, the derivative of acceleration, frequency factors, etc. for the accelerations, and the ranges and RMS for the angular velocity. Our findings show that smartphone devices have good consistency over multiple trials and between devices, and motion patterns achieved from multiple data points are reliable for postural stability analysis.
帕金森病(PD)是美国第二大最常见的神经退行性疾病。帕金森病的主要症状是震颤、僵硬、运动迟缓和平衡受损。这些症状通常会干扰帕金森病患者(PwPD)的日常活动,并对生活质量(QoL)产生负面影响。因此,监测帕金森病症状对于临床评估和调整药物以帮助维持帕金森病患者的生活质量至关重要。我们正在开发一款手机应用程序,用于在家监测帕金森病症状,以便更及时、更频繁、更准确地测量帕金森病症状。虽然手机应用中收集的震颤和手指敲击结果已在以前的出版物中讨论过,但本文重点讨论应用中姿势稳定性测试的设计和评估,以及验证智能手机中嵌入式加速度计和陀螺仪的可靠性。在测试过程中,我们使用了振动器来提供振幅和频率范围与人体姿势稳定性信号相似的振动,并对加速度计和陀螺仪的测量结果进行了评估。我们使用信号处理算法来提取姿势稳定性因子,如加速度的均方根值、加速度导数、频率因子等,以及角速度的范围和均方根值。我们的研究结果表明,智能手机设备在多次试验和设备之间具有良好的一致性,从多个数据点获得的运动模式对于姿势稳定性分析是可靠的。
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引用次数: 0
Biomechanical Analysis of Orthodontic Miniscrew-Assisted Rapid Palatal Expansion On Dental and Bone Tissues: A Finite-Element Study 正畸微型螺钉辅助快速腭扩展对牙齿和骨组织的生物力学分析:有限元研究
Pub Date : 2024-05-24 DOI: 10.1115/1.4065589
Egon Mamboleo, Abdelhak Ouldyerou, Khaled Alsharif, Peter Ngan, A. Merdji, Sandipan Roy, O. Mukdadi
This study aims to delineate the biomechanical responses in both soft and hard tissues, alongside the interactions within the surrounding bone of a human skull subjected to clinical loadings generated by a miniscrew-assisted rapid palatal expansion (MARPE) device. Cone-beam computed tomography (CBCT) scans of a 20-year-old female skull were segmented. The skull bones were meticulously modeled to reconstruct a comprehensive 3D model for finite-element analysis (FEA). A displacement of 0.125 mm was applied on each side (0.25 mm total) of the MARPE device to simulate one complete turn of the jackscrew. The outcomes revealed that the miniscrews experienced a maximum equivalent von Mises stress of 264.91 MPa. Notably, the separation of the midpalatal suture exhibited a quasi-parallel deformation with an average displacement of 0.247 mm and a standard deviation of 0.00667 mm. The ratio of the rotational angle to the lateral displacement of the zygomaticomaxillary complex was 0.6436 degree/mm. No Fracture of miniscrews was observed during the activation of one turn per day.
本研究旨在描述软组织和硬组织的生物力学反应,以及在微型螺钉辅助快速腭部扩张(MARPE)装置产生的临床载荷作用下人头骨周围骨骼的相互作用。对一个 20 岁女性头骨的锥形束计算机断层扫描(CBCT)进行了分割。对头骨进行了细致的建模,以重建用于有限元分析(FEA)的综合三维模型。在 MARPE 装置的两侧各施加 0.125 毫米(总计 0.25 毫米)的位移,以模拟千斤顶螺杆旋转一圈。结果显示,微型螺杆的最大等效冯米斯应力为 264.91 兆帕。值得注意的是,腭中缝的分离呈现准平行变形,平均位移为 0.247 毫米,标准偏差为 0.00667 毫米。颧颌复合体旋转角度与侧向位移之比为 0.6436 度/毫米。在每天一圈的激活过程中,未发现微型螺钉断裂。
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引用次数: 0
Design of a Device to Ease and Improve the Diagnosis of Popliteal Artery Entrapment Syndrome (paes) 设计一种设备以简化和改进腘动脉闭锁综合征的诊断 (paes)
Pub Date : 2024-05-24 DOI: 10.1115/1.4065588
Emma Rutherford, Wenhao Xu, Kiet Vu, Claudia Lozano, Alexandra Lee, Paige Dzenutis, Arriyan Dowlatshahi, Anthony Pennes, Jay Connor, Alexander Slocum
Popliteal Artery Entrapment Syndrome (PAES) is a condition affecting blood flow in the back of the leg which can have a significant impact on the patient's life. It is often misdiagnosed due to a lack of standardized procedures and quantifiable diagnostic criteria. To facilitate easier and more accurate diagnosis of this syndrome, we have designed and built an initial prototype of a device that provides adjustable resistance during plantar-flexion of the patient's ankle while quantifying force generated and ankle range of motion. The device will be used while the physician observes blood flow through the popliteal artery in the back of the knee using an ultrasound. The device provides a convenient and ergonomic solution for patients and physicians, which helps improve the accuracy of Popliteal Artery Entrapment Syndrome (PAES) diagnosis and allows physicians to further study this condition.
腘动脉夹层综合症(PAES)是一种影响腿部后侧血流的疾病,会对患者的生活产生重大影响。由于缺乏标准化程序和可量化的诊断标准,这种疾病经常被误诊。为了更方便、更准确地诊断这种综合症,我们设计并制造了一个设备的初始原型,它能在患者踝关节跖屈时提供可调节的阻力,同时量化产生的力和踝关节的活动范围。使用该装置时,医生将使用超声波观察膝关节后部腘动脉的血流情况。该设备为患者和医生提供了方便且符合人体工程学的解决方案,有助于提高腘动脉闭锁综合症 (PAES) 诊断的准确性,并使医生能够进一步研究这种疾病。
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引用次数: 0
Comparison of Load-Sharing Responses Between Graded Posterior Cervical Foraminotomy and Conventional Fusion Using Finite Element Modeling. 应用有限元模型比较分级颈后切口和常规融合的负荷分担反应。
Pub Date : 2024-05-01 Epub Date: 2023-10-09 DOI: 10.1115/1.4063465
Narayan Yoganandan, Hoon Choi, Yuvaraj Purushothaman, Aditya Vedantam, Balaji Harinathan, Anjishnu Banerjee

Following the diagnosis of unilateral cervical radiculopathy and need for surgical intervention, anterior cervical diskectomy and fusion (conventional fusion) and posterior cervical foraminotomy are common options. Although patient outcomes may be similar between the two procedures, their biomechanical effects have not been fully compared using a head-to-head approach, particularly, in relation to the amount of facet resection and internal load-sharing between spinal segments and components. The objective of this investigation was to compare load-sharing between conventional fusion and graded foraminotomy facet resections under physiological loading. A validated finite element model of the cervical spinal column was used in the study. The intact spine was modified to simulate the two procedures at the C5-C6 spinal segment. Flexion, extension, and lateral bending loads were applied to the intact, graded foraminotomy, and conventional fusion spines. Load-sharing was determined using range of motion data at the C5-C6 and immediate adjacent segments, facet loads at the three segments, and disk pressures at the adjacent segments. Results were normalized with respect to the intact spine to compare surgical options. Conventional fusion leads to increased motion, pressure, and facet loads at adjacent segments. Foraminotomy leads to increased motion and anterior loading at the index level, and motions decrease at adjacent levels. In extension, the left facet load decreases after foraminotomy. Recognizing that foraminotomy is a motion preserving alternative to conventional fusion, this study highlights various intrinsic biomechanical factors and potential instability issues with more than one-half facet resection.

在诊断为单侧颈神经根病并需要手术干预后,颈前路椎间盘切除融合术(常规融合术)和颈前路椎间孔切开术是常见的选择。尽管两种手术的患者结果可能相似,但使用头对头方法尚未完全比较其生物力学效果,特别是在小关节切除量以及脊柱节段和部件之间的内部载荷分担方面。本研究的目的是比较生理负荷下常规椎间孔融合术和分级小关节切除术的负荷分担情况。研究中使用了一个经过验证的颈椎有限元模型。对完整的脊柱进行了修改,以模拟C5-C6脊柱节段的两个过程。对完整、分级的椎间孔切开术和常规融合棘施加弯曲、伸展和侧向弯曲载荷。使用C5-C6和紧邻节段的运动范围数据、三个节段的端面载荷以及相邻节段的圆盘压力来确定载荷分担。对完整脊柱的结果进行标准化,以比较手术选择。传统的融合导致相邻节段处的运动、压力和小平面载荷增加。For氨基切开术导致指数水平的运动和前负荷增加,相邻水平的运动减少。在延伸过程中,椎间孔切开术后左小面负荷降低。鉴于椎间孔切开术是传统融合术的一种保留运动的替代方法,本研究强调了超过一半的小关节切除术的各种内在生物力学因素和潜在的不稳定性问题。
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引用次数: 0
期刊
Journal of engineering and science in medical diagnostics and therapy
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