{"title":"Invitro free radical scavenging, cytotoxic and acetylcholinesterase inhibitory activities of Leucas martinicensis","authors":"Ramani Ramalingam , Anisetti Ravinder Nath , Boddupalli Bindu Madhavi , Malothu Nagulu","doi":"10.1016/j.ijcas.2013.04.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>In recent years oxidative stress was found to play the significant role in causing various diseases, including neurodegenerative disorders like, Alzheimer's. Lack of antioxidant mechanisms is the major cause for increased oxidative stress. Flavonoids and phenolic compounds from herbs are going to play efficient role in scavenging the free radicals responsible for oxidative stress. Present investigation deals with the free radical scavenging activity of <em>Leucas</em> species in relation to neurodegenerative disorder.</p></div><div><h3>Methods</h3><p>Ethanolic extract of selected plant was estimated for phenolic and flavonoids contents and then screened for free radical scavenging activity with various oxygen radicals. The extract was further tested <em>invitro</em> for acetylcholinesterase inhibitory activity along with cytotoxic activity.</p></div><div><h3>Results</h3><p>The extract was found to contain 42.28 ± 8.88 RE/g of flavonoids and 38.624 ± 14.171 GAE/g of phenolic compounds along with significant free radical scavenging activity in comparison with the standard Quercetin. The extract was found to be non cytotoxic with no inhibitory activity on acetylcholinesterase.</p></div><div><h3>Conclusion</h3><p>Inspite of its inability to inhibit acetylcholinesterase, the selected plant extract can be safely used for treating neurodegenerative disorders like Alzheimer's because of its effective free radical scavenging activity.</p></div>","PeriodicalId":100693,"journal":{"name":"International Journal of Chemical and Analytical Science","volume":"4 2","pages":"Pages 91-95"},"PeriodicalIF":0.0000,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ijcas.2013.04.005","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Chemical and Analytical Science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0976120913000235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Aim
In recent years oxidative stress was found to play the significant role in causing various diseases, including neurodegenerative disorders like, Alzheimer's. Lack of antioxidant mechanisms is the major cause for increased oxidative stress. Flavonoids and phenolic compounds from herbs are going to play efficient role in scavenging the free radicals responsible for oxidative stress. Present investigation deals with the free radical scavenging activity of Leucas species in relation to neurodegenerative disorder.
Methods
Ethanolic extract of selected plant was estimated for phenolic and flavonoids contents and then screened for free radical scavenging activity with various oxygen radicals. The extract was further tested invitro for acetylcholinesterase inhibitory activity along with cytotoxic activity.
Results
The extract was found to contain 42.28 ± 8.88 RE/g of flavonoids and 38.624 ± 14.171 GAE/g of phenolic compounds along with significant free radical scavenging activity in comparison with the standard Quercetin. The extract was found to be non cytotoxic with no inhibitory activity on acetylcholinesterase.
Conclusion
Inspite of its inability to inhibit acetylcholinesterase, the selected plant extract can be safely used for treating neurodegenerative disorders like Alzheimer's because of its effective free radical scavenging activity.
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