No Direct Association of Myelin Oligodendrocyte Glycoprotein (MOG) Gene Polymorphism (Val142leu) in Genetic Susceptibility to Migraine

Abstract

Objective: Genes which are involved in immune response portray possible candidate genes in migraine. One of those genes is that myelin oligodendrocyte glycoprotein (MOG) that plays an important role in mediating the complement cascade. The purpose of our study is to show the effect of MOG G511C (Val142Leu; rs2857766) polymorphism in migraine attack frequency. Materials and Methods: In the cohort of 101 Turkish migraine patients and in a control group of 101 healthy subjects, MOG Val142Leu alleles’ distribution was examined. Restriction fragment length polymorphism (RFLP) was carried out to genotype this polymorphism. Results: Although MOG Leu allele frequency was determined as under-represented in migraine patients, any significant difference between the patient and control groups’ genotype, and allele frequencies were not obtained [OR=0.47 (0.21-1.08), p=0.053 for genotypes; OR=0.50 (0.23-1.11), p=0.060 for alleles]. However, a statistically significant relationship between MOG G511C (Val142Leu) polymorphism and the decreased migraine attack frequency was determined [OR=11.71 (1.32-103.77), p=0.013]. Val/Leu genotype frequency increrased in migraine patients with two or fewer attacks per month. Conclusion: Migraine attack frequency might be related with MOG Val142Leu heterozygote genotype. So we think that MOG gene might be related to genetic susceptibility to migraine in the human leukocyte antigen (HLA) region.