L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz
{"title":"A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation","authors":"L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz","doi":"10.1084/jem.20182111","DOIUrl":null,"url":null,"abstract":"Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 signaling protects against helminth infections.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"4 1","pages":"2763 - 2777"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"36","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20182111","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 36
Abstract
Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 signaling protects against helminth infections.