Clarification of the irritating and toxic effects of bentonite-like clays

Abstract

This article studies the action and biocompatibility of the developed montmorillonite-containing preparation “Sorbent” on experimental animals with its longterm use. The local irritating effect of the “Sorbent” preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs. To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose 600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index. Keywords—enterosorbent, montmorillonite, ulcerative pathology, inflammatory process