Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter
{"title":"Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer","authors":"Wenhan Zhu, N. Miyata, M. Winter, A. Arenales, Elizabeth R Hughes, Luisella Spiga, Jiwoong Kim, Luis Sifuentes-Dominguez, P. Starokadomskyy, P. Gopal, Mariana X. Byndloss, R. Santos, E. Burstein, S. Winter","doi":"10.1084/jem.20181939","DOIUrl":null,"url":null,"abstract":"Enterobacteriaceae family members such as E. coli exacerbate development of intestinal malignancy. Zhu et al. report that targeting the metabolism of protumoral Enterobacteriaceae by tungstate prevents tumor development in murine models of colitis-associated colorectal cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"17 1","pages":"2378 - 2393"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"76","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20181939","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 76
Abstract
Enterobacteriaceae family members such as E. coli exacerbate development of intestinal malignancy. Zhu et al. report that targeting the metabolism of protumoral Enterobacteriaceae by tungstate prevents tumor development in murine models of colitis-associated colorectal cancer.