Serum Uromodulin in Children and Adolescents with Type 1 Diabetes Mellitus and Controls: Its Potential Role in Kidney Health.

IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-03-01 DOI:10.1055/a-1944-2686
Ralf Schiel, Mathias Block, Günter Stein, Antje Steveling, Sarah Lücking, Jürgen Scherberich
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引用次数: 2

Abstract

Introduction: Uromodulin is a kidney-specific tubular protein, and its assessment in serum (sUMOD) reveals the potential as a novel marker for function and the integrity of renal parenchymal cells and does not directly depend on the glomerular filtration rate. Early diabetic nephropathy parallels glomerular hyperfiltration, often leading to diagnostic misinterpretation. Moreover, traditional kidney function markers are not able to diagnose structural lesions. Recent data show that sUMOD is linked to glucose intolerance in adults. Thus, we launched to assess the hypothesis that sUMOD is also associated with kidney function, biometric data, and quality of metabolic control in children/adolescents with type 1 diabetes.

Patients and methods: Patients with type 1 diabetes (n=135) and healthy controls (n=69) were recruited to participate in the trial. Clinical, biometrical data, sUMOD, and other laboratory parameters were assessed.

Results: The mean concentrations of sUMOD in diabetic patients and controls were comparable (201.19±103.22 vs. 198.32±84.27 ng/mL, p=0.832). However, in contrast to healthy controls, sUMOD levels in patients with diabetes were associated with serum-creatinine (r=-0.368, p<0.0001), age (r=-0.350, p<0.0001), height (r=-0.379, p<0.0001), body weight (r=-0.394, p<0.0001), Body mass index (r=-0.292, p=0.001), daily insulin dosage (r=-0.300, p<0.0001), HbA1c (%) (r=-0.190, p=0.027), standardized HbA1c/IFCC (mmol/mol) (r=-0.189, p=0.028), and systolic (r=-0.299, p<0.0001) and diastolic (r=-0.235, p=0.006) arterial blood pressure.

Conclusions: Our study shows that children/adolescents with type 1 diabetes disclose similar sUMOD concentrations as healthy controls. Serum UMOD appears to indicate higher risks for kidney tissue remodeling and possibly subsequent cardiovascular alterations. However, further studies are mandatory to settle these findings.

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1型糖尿病儿童和青少年及其对照组血清尿调蛋白:其在肾脏健康中的潜在作用
尿调素是一种肾特异性小管蛋白,其在血清中的评估(sUMOD)揭示了作为肾实质细胞功能和完整性的新标志物的潜力,并且不直接依赖于肾小球滤过率。早期糖尿病肾病与肾小球高滤过相似,常导致诊断上的误解。此外,传统的肾功能指标不能诊断结构性病变。最近的数据显示,sUMOD与成人葡萄糖耐受不良有关。因此,我们开始评估sUMOD也与1型糖尿病儿童/青少年的肾功能、生物特征数据和代谢控制质量相关的假设。患者和方法:招募1型糖尿病患者(n=135)和健康对照者(n=69)参加试验。评估临床、生物特征数据、sUMOD和其他实验室参数。结果:糖尿病患者与对照组的sUMOD平均浓度具有可比性(201.19±103.22∶198.32±84.27 ng/mL, p=0.832)。然而,与健康对照相比,糖尿病患者的sUMOD水平与血清肌酐相关(r=-0.368)。结论:我们的研究表明,1型糖尿病儿童/青少年的sUMOD浓度与健康对照相似。血清UMOD似乎表明肾脏组织重塑和随后可能发生的心血管改变的风险较高。然而,为了解决这些发现,还需要进一步的研究。
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来源期刊
CiteScore
4.10
自引率
5.60%
发文量
72
审稿时长
3 months
期刊介绍: Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!
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