Tinn Hongboontry, Surada Ponwaranon, Supphakorn Sirijongdee, C. Thanachayanont, P. Pungetmongkol
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引用次数: 5
Abstract
Creatinine, a metabolized product of phosphocreatine in muscles, is excreted via urine by kidneys. Creatinine concentration in urine is an indicator of renal function for a patient with chronic kidney disease. A single-use and portable screen-printed carbon electrode with copper oxide nanostructure was developed for creatinine detection via copper-creatinine complex formation. SEM was deployed to visualize the copper oxide nanostructure. Creatinine measurement was performed in 0.1 M PBS at pH 6.5 with a smartphone application and portable near-field communication potentiostat. Five chemicals were tested as interferences. The CuO/SPCE shows linear and repeatable responses of creatinine from 0–30 mM, which makes it an appealing alternative for quick and reliable CRE detection.
肌酸酐是肌肉中磷酸肌酸的代谢产物，由肾脏通过尿液排出。尿肌酐浓度是慢性肾病患者肾功能的一个指标。通过铜-肌酸酐络合物的形成，制备了一种具有氧化铜纳米结构的一次性便携式丝网印刷碳电极，用于肌酸酐的检测。利用扫描电镜观察氧化铜纳米结构。肌酐测量在0.1 M PBS中进行，pH为6.5，使用智能手机应用程序和便携式近场通信电位器。测试了五种化学物质作为干扰物。CuO/SPCE在0-30 mM范围内对肌酐具有线性和可重复的响应，这使其成为快速可靠的CRE检测的一种有吸引力的替代方法。
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