Obtaining and study of the physicochemical properties of hydrogel ointments based on the complex of poly(2-ethyl-2-oxazoline) with iodine and carbopol

Abstract

Hydrogel ointments based on complex of poly(2-ethyl-2-oxazoline) with iodine and carbopol 940 as a gel base were obtained. The rheological properties of hydrogels have been studied. It has been established that the viscosity characteristics of the gels depend only on concentration of carbopol 940 and presence of polymeric iodophor complex does not affect their rheological properties. The study of release of iodine from obtained hydrogels using Frans cell installation showed that samples of carbopol 940-POZ-iodine/iodide release the smallest amount of iodine and show a prolonging effect. The possibility of using hydrogel ointments as dosage forms for treatment of skin diseases has been studied. It is shown that obtained gel samples are able to stay on the skin surface in the flush mode for 40 minutes, while there is no staining of the skin with iodine.