Assay of some non-steroidal anti-inflammatory drugs with ammonium hexanitratocerate (IV) reagent

International Journal of Chemical and Analytical Science Pub Date : 2013-06-01 DOI:10.1016/j.ijcas.2013.03.007

Vinod Kumar, Brijesh Kumar Singh, Ishwar Chandra Shukla

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引用次数: 1

Abstract

In the present paper we have reported a simple and convenient titrimetric method for determination of non-steroidal anti-inflammatory drugs (NSAIDs) e.g. aceclofenac, diclofenac sodium, ibuprofen, mefenamic acid and nimesulide in pure form and in their pharmaceutical preparations such as acecloren (Tab), aclofen (Tab), voveran (Tab), diclomax (Inj), brufen (Tab), norswell (Tab), meftal (Tab), mef-T (Tab), nicip-DT (Tab) and dolamide (Tab) with ammonium hexanitratocerate (AHC) reagent. It is a versatile oxidizing agent of cerium (IV) and is being widely used as an oxidant for several classes of organic compounds. During estimation it was noted that the excipients present in pharmaceutical preparations do not interfere. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) prove the method to be precise and reproducible. To establish authenticity of the method, recovery experiments were also carried out by standard drug addition method.

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几种非甾体类抗炎药的六硝酸铵(IV)试剂测定

本文报道了一种简单、便捷的滴定法，用己胺酸铵(AHC)试剂测定非甾体抗炎药(非甾体抗炎药)如乙酰氯芬酸、双氯芬酸钠、布洛芬、甲氧胺酸和尼美舒利的纯制剂及其制剂如乙酰氯芬酸(Tab)、氯芬酸(Tab)、维佛兰(Tab)、双氯美ax (Inj)、布鲁芬(Tab)、诺斯威(Tab)、金属(Tab)、mef-T (Tab)、nip - dt (Tab)和dolamide (Tab)。它是铈(IV)的一种多用途氧化剂，被广泛用作几种有机化合物的氧化剂。在估计期间，注意到药物制剂中存在的赋形剂不会干扰。误差百分率、变异系数和标准差均证明了该方法的精确性和重复性。为验证方法的真实性，采用标准药物加样法进行了回收率实验。

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International Journal of Chemical and Analytical Science

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