{"title":"Antimicrobial Activity, In Vitro, of Chlorhexidine*","authors":"C.A. Lawrence","doi":"10.1002/jps.3030491113","DOIUrl":null,"url":null,"abstract":"<div><p>Comparative <em>in vitro</em> tests indicate that chlorhexidine has greater antibacterial activity than benzalkonium chloride, a combination of <em>o</em>-phenyl- and <em>p</em>-<em>tert</em>-amyl-phenol, and an iodine-polyvinylpyrrolidone complex under the test conditions. Chlorhexidine in relatively high dilutions was effective against several cultures of Gram-negative bacteria in the phenol coefficient test. In moderate concentrations, it was active against staphylococci and anaerobes.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Pages 731-734"},"PeriodicalIF":0.0000,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491113","citationCount":"39","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315363794","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 39
Abstract
Comparative in vitro tests indicate that chlorhexidine has greater antibacterial activity than benzalkonium chloride, a combination of o-phenyl- and p-tert-amyl-phenol, and an iodine-polyvinylpyrrolidone complex under the test conditions. Chlorhexidine in relatively high dilutions was effective against several cultures of Gram-negative bacteria in the phenol coefficient test. In moderate concentrations, it was active against staphylococci and anaerobes.