pyPheWAS Explorer: a visualization tool for exploratory analysis of phenome-disease associations.

IF 2.5 Q2 HEALTH CARE SCIENCES & SERVICES JAMIA Open Pub Date : 2023-04-03 eCollection Date: 2023-04-01 DOI:10.1093/jamiaopen/ooad018
Cailey I Kerley, Tin Q Nguyen, Karthik Ramadass, Laurie E Cutting, Bennett A Landman, Matthew Berger
{"title":"pyPheWAS Explorer: a visualization tool for exploratory analysis of phenome-disease associations.","authors":"Cailey I Kerley, Tin Q Nguyen, Karthik Ramadass, Laurie E Cutting, Bennett A Landman, Matthew Berger","doi":"10.1093/jamiaopen/ooad018","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To enable interactive visualization of phenome-wide association studies (PheWAS) on electronic health records (EHR).</p><p><strong>Materials and methods: </strong>Current PheWAS technologies require familiarity with command-line interfaces and lack end-to-end data visualizations. pyPheWAS Explorer allows users to examine group variables, test assumptions, design PheWAS models, and evaluate results in a streamlined graphical interface.</p><p><strong>Results: </strong>A cohort of attention deficit hyperactivity disorder (ADHD) subjects and matched non-ADHD controls is examined. pyPheWAS Explorer is used to build a PheWAS model including sex and deprivation index as covariates, and the Explorer's result visualization for this model reveals known ADHD comorbidities.</p><p><strong>Discussion: </strong>pyPheWAS Explorer may be used to rapidly investigate potentially novel EHR associations. Broader applications include deployment for clinical experts and preliminary exploration tools for institutional EHR repositories.</p><p><strong>Conclusion: </strong>pyPheWAS Explorer provides a seamless graphical interface for designing, executing, and analyzing PheWAS experiments, emphasizing exploratory analysis of regression types and covariate selection.</p>","PeriodicalId":36278,"journal":{"name":"JAMIA Open","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070037/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JAMIA Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/jamiaopen/ooad018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/4/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To enable interactive visualization of phenome-wide association studies (PheWAS) on electronic health records (EHR).

Materials and methods: Current PheWAS technologies require familiarity with command-line interfaces and lack end-to-end data visualizations. pyPheWAS Explorer allows users to examine group variables, test assumptions, design PheWAS models, and evaluate results in a streamlined graphical interface.

Results: A cohort of attention deficit hyperactivity disorder (ADHD) subjects and matched non-ADHD controls is examined. pyPheWAS Explorer is used to build a PheWAS model including sex and deprivation index as covariates, and the Explorer's result visualization for this model reveals known ADHD comorbidities.

Discussion: pyPheWAS Explorer may be used to rapidly investigate potentially novel EHR associations. Broader applications include deployment for clinical experts and preliminary exploration tools for institutional EHR repositories.

Conclusion: pyPheWAS Explorer provides a seamless graphical interface for designing, executing, and analyzing PheWAS experiments, emphasizing exploratory analysis of regression types and covariate selection.

Abstract Image

Abstract Image

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
pyPheWAS Explorer:表型-疾病关联探索性分析的可视化工具。
目的在电子健康记录(EHR)上实现表观范围关联研究(PheWAS)的交互式可视化:pyPheWAS Explorer 允许用户在一个精简的图形界面上检查组变量、测试假设、设计 PheWAS 模型并评估结果:pyPheWAS Explorer 用于建立一个 PheWAS 模型,将性别和贫困指数作为协变量,Explorer 对该模型的结果可视化显示了已知的多动症合并症。讨论:pyPheWAS Explorer 可用于快速调查潜在的新电子病历关联。结论:pyPheWAS Explorer 为设计、执行和分析 PheWAS 实验提供了无缝的图形界面,强调回归类型和协方差选择的探索性分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
JAMIA Open
JAMIA Open Medicine-Health Informatics
CiteScore
4.10
自引率
4.80%
发文量
102
审稿时长
16 weeks
期刊最新文献
A landmark federal interagency collaboration to promote data science in health care: Million Veteran Program-Computational Health Analytics for Medical Precision to Improve Outcomes Now. Targetable molecular algorithm and training platform development for the treatment of non-small cell lung cancer. Sex, sexual orientation, and gender identity data collection across electronic health record platforms: a national cross-sectional survey. Assessing the use of unstructured electronic health record data to identify exposure to firearm violence. Developing personas to inform the design of digital interventions for perinatal mental health.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1