pyPheWAS Explorer: a visualization tool for exploratory analysis of phenome-disease associations.

IF 2.5 Q2 HEALTH CARE SCIENCES & SERVICES JAMIA Open Pub Date : 2023-04-03 eCollection Date: 2023-04-01 DOI:10.1093/jamiaopen/ooad018
Cailey I Kerley, Tin Q Nguyen, Karthik Ramadass, Laurie E Cutting, Bennett A Landman, Matthew Berger
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Abstract

Objective: To enable interactive visualization of phenome-wide association studies (PheWAS) on electronic health records (EHR).

Materials and methods: Current PheWAS technologies require familiarity with command-line interfaces and lack end-to-end data visualizations. pyPheWAS Explorer allows users to examine group variables, test assumptions, design PheWAS models, and evaluate results in a streamlined graphical interface.

Results: A cohort of attention deficit hyperactivity disorder (ADHD) subjects and matched non-ADHD controls is examined. pyPheWAS Explorer is used to build a PheWAS model including sex and deprivation index as covariates, and the Explorer's result visualization for this model reveals known ADHD comorbidities.

Discussion: pyPheWAS Explorer may be used to rapidly investigate potentially novel EHR associations. Broader applications include deployment for clinical experts and preliminary exploration tools for institutional EHR repositories.

Conclusion: pyPheWAS Explorer provides a seamless graphical interface for designing, executing, and analyzing PheWAS experiments, emphasizing exploratory analysis of regression types and covariate selection.

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pyPheWAS Explorer:表型-疾病关联探索性分析的可视化工具。
目的在电子健康记录(EHR)上实现表观范围关联研究(PheWAS)的交互式可视化:pyPheWAS Explorer 允许用户在一个精简的图形界面上检查组变量、测试假设、设计 PheWAS 模型并评估结果:pyPheWAS Explorer 用于建立一个 PheWAS 模型,将性别和贫困指数作为协变量,Explorer 对该模型的结果可视化显示了已知的多动症合并症。讨论:pyPheWAS Explorer 可用于快速调查潜在的新电子病历关联。结论:pyPheWAS Explorer 为设计、执行和分析 PheWAS 实验提供了无缝的图形界面,强调回归类型和协方差选择的探索性分析。
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来源期刊
JAMIA Open
JAMIA Open Medicine-Health Informatics
CiteScore
4.10
自引率
4.80%
发文量
102
审稿时长
16 weeks
期刊最新文献
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