Elevated fibrinogen to pre-albumin ratio predicts mortality in peritoneal dialysis patients.

IF 1.4 4区医学 Q3 UROLOGY & NEPHROLOGY Seminars in Dialysis Pub Date : 2024-01-01 Epub Date: 2023-05-29 DOI:10.1111/sdi.13159

Wenkai Xia, Xi Hua, Dong Sun, Xiangcheng Xie, Meisi Kuang, Hong Hu

{"title":"Elevated fibrinogen to pre-albumin ratio predicts mortality in peritoneal dialysis patients.","authors":"Wenkai Xia, Xi Hua, Dong Sun, Xiangcheng Xie, Meisi Kuang, Hong Hu","doi":"10.1111/sdi.13159","DOIUrl":null,"url":null,"abstract":"Background: Fibrinogen to pre-albumin ratio (FPR) is a promising predictor of mortality in various cancers. The aim of this study was to explore the prognostic value of FPR to predict mortality in peritoneal dialysis (PD) patients.Methods: We retrospectively analyzed 324 incident PD patients form January 2011 to December 2020. Patients were stratified based on the optimal thresholds for FPR at baseline to predict overall and cardiovascular mortality during follow-up. The association of FPR and all-cause and cardiovascular mortality was evaluated by Kaplan-Meier curve and Cox regression analysis.Results: All patients were divided into three groups based on the optimal cutoff value of FPR. Higher FPR levels were strongly correlated with worse overall and cardiovascular mortality in PD patients. Compared with patients in the lowest FPR tertile (<14.3), those in the highest terile (≥18.8) had multivariable-adjusted hazard ratios (95% CI confidence interval) of 3.37 (1.76-6.49) and 2.86 (1.31-6.23) for all-cause and cardiovascular mortality, respectively. Significant differences in overall survival were observed across nearly all subgroups after stratification.Conclusions: Patients with a high FPR had increased all-cause and cardiovascular mortality. FPR is a potential prognostic indicator in PD patients.","PeriodicalId":21675,"journal":{"name":"Seminars in Dialysis","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Dialysis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/sdi.13159","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/5/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Fibrinogen to pre-albumin ratio (FPR) is a promising predictor of mortality in various cancers. The aim of this study was to explore the prognostic value of FPR to predict mortality in peritoneal dialysis (PD) patients.

Methods: We retrospectively analyzed 324 incident PD patients form January 2011 to December 2020. Patients were stratified based on the optimal thresholds for FPR at baseline to predict overall and cardiovascular mortality during follow-up. The association of FPR and all-cause and cardiovascular mortality was evaluated by Kaplan-Meier curve and Cox regression analysis.

Results: All patients were divided into three groups based on the optimal cutoff value of FPR. Higher FPR levels were strongly correlated with worse overall and cardiovascular mortality in PD patients. Compared with patients in the lowest FPR tertile (<14.3), those in the highest terile (≥18.8) had multivariable-adjusted hazard ratios (95% CI confidence interval) of 3.37 (1.76-6.49) and 2.86 (1.31-6.23) for all-cause and cardiovascular mortality, respectively. Significant differences in overall survival were observed across nearly all subgroups after stratification.

Conclusions: Patients with a high FPR had increased all-cause and cardiovascular mortality. FPR is a potential prognostic indicator in PD patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

纤维蛋白原与前白蛋白比率升高可预测腹膜透析患者的死亡率。

背景：纤维蛋白原与前白蛋白比值（FPR）是预测各种癌症死亡率的有效指标。本研究旨在探讨 FPR 在预测腹膜透析（PD）患者死亡率方面的预后价值：我们对 2011 年 1 月至 2020 年 12 月期间的 324 例腹膜透析患者进行了回顾性分析。根据基线 FPR 的最佳阈值对患者进行分层，以预测随访期间的总死亡率和心血管死亡率。通过卡普兰-梅耶曲线和考克斯回归分析评估了FPR与全因死亡率和心血管死亡率的关系：结果：根据 FPR 的最佳临界值，所有患者被分为三组。FPR水平越高，PD患者的总死亡率和心血管死亡率越低。与 FPR 最低三等分组的患者相比（结论：FPR 较高的患者总体死亡率和心血管死亡率更高：FPR较高的患者全因死亡率和心血管死亡率均有所上升。FPR是一种潜在的帕金森病预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Seminars in Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

6.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.