短时视觉刺激下人脑中γ-氨基丁酸浓度的动态变化。

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2024-02-01 Epub Date: 2023-09-16 DOI:10.1007/s10334-023-01118-7
Alexey Yakovlev, Alexandra Gritskova, Andrei Manzhurtsev, Maxim Ublinskiy, Petr Menshchikov, Anatoly Vanin, Dmitriy Kupriyanov, Tolib Akhadov, Natalia Semenova
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引用次数: 0

摘要

目的材料与方法:使用 3 T 磁共振扫描仪获取 33 名受试者视觉皮层激活区域的 fMRI 数据和 MEGA-PRESS 磁共振频谱[回波时间(TE)/重复时间(TR)= 68 ms/1500 ms]。GABA 和肌酸(Cr)浓度的时间过程以及共振线的宽度和高度均以 1.5 秒的标称时间分辨率获得。N-乙酰天冬氨酸(NAA)和 Cr 信号线宽和高度的变化用于确定 BOLD 效应:结果:刺激开始后 1.6 秒和 3.1 秒,BOLD 校正 GABA + /Cr 比率分别增加了 5.0% (q = 0.027) 和 3.8% (q=0.048)。Cr 和 NAA 信号宽度和高度的时间进程在第 6 秒达到最大变化(约 1.2-1.5%,q 结论):观察到的 GABA 浓度对短时刺激的快速反应很可能是由于 GABA 从囊泡中释放,然后又被包裹回囊泡中。
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Dynamics of γ-aminobutyric acid concentration in the human brain in response to short visual stimulation.

Objective: To find a possible quantitative relation between activation-induced fast (< 10 s) changes in the γ-aminobutyric acid (GABA) level and the amplitude of a blood oxygen level-dependent contrast (BOLD) response (according to magnetic resonance spectroscopy [MRS] and functional magnetic resonance imaging [fMRI]).

Materials and methods: fMRI data and MEGA-PRESS magnetic resonance spectra [echo time (TE)/repetition time (TR) = 68 ms/1500 ms] of an activated area in the visual cortex of 33 subjects were acquired using a 3 T MR scanner. Stimulation was performed by presenting an image of a flickering checkerboard for 3 s, repeated with an interval of 13.5 s. The time course of GABA and creatine (Cr) concentrations and the width and height of resonance lines were obtained with a nominal time resolution of 1.5 s. Changes in the linewidth and height of n-acetylaspartate (NAA) and Cr signals were used to determine the BOLD effect.

Results: In response to the activation, the BOLD-corrected GABA + /Cr ratio increased by 5.0% (q = 0.027) and 3.8% (q = 0.048) at 1.6 and 3.1 s, respectively, after the start of the stimulus. Time courses of Cr and NAA signal width and height reached a maximum change at the 6th second (~ 1.2-1.5%, q < 0.05).

Conclusion: The quick response of the observed GABA concentration to the short stimulus is most likely due to a release of GABA from vesicles followed by its packaging back into vesicles.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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