心脏迷走神经活动与女性肠道微生物群模式相关——一项探索性初步研究。

IF 8.3 2区 医学 Q1 Medicine Dialogues in Clinical Neuroscience Pub Date : 2022-01-01 DOI:10.1080/19585969.2022.2128697
Sabrina Mörkl, Andreas Oberascher, Josef M Tatschl, Sonja Lackner, Thomaz F S Bastiaanssen, Mary I Butler, Maximilian Moser, Matthias Frühwirth, Harald Mangge, John F Cryan, Timothy G Dinan, Sandra J Holasek
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引用次数: 6

摘要

导读:肠道微生物群和迷走神经活动之间的功能互惠已被提出,然而,针对这一现象的人类研究是有限的。方法:对73名女性(年龄24.5±4.3岁)进行24小时心脏迷走神经活动(CVA)评估。此外,粪便样本进行16SrRNA基因分析(V1-V2)。微生物生态学定量洞察(QIIME)用于分析微生物组数据。此外,从血清样本中提取炎症参数(如CRP和IL-6)。结果:白天CVA与肠道菌群多样性(r sp = 0.254, p = 0.030)、CRP (r sp = -0.348, p = 0.003)、IL-6 (r sp = -0.320, p = 0.006)显著相关。在24 h CVA中位数(Mdn = 1.322)分组时,高CVA组的以下特征更为丰富:梭菌(线性判别分析效应值(LDA) = 4.195, p = 0.029)、梭菌(LDA = 4.195, p = 0.029)、毛螺旋体(LDA = 3.489, p = 0.004)、瘤胃球菌科(LDA = 4.073, p = 0.010)、粪杆菌(LDA = 3.982, p = 0.042)、乳酸杆菌(LDA = 3.317, p = 0.029)、杆菌(LDA = 3.294, p = 0.0350)、链球菌科(LDA = 3.353, p = 0.006)、链球菌(LDA = 3.332, p = 0.011)。基于Dirichlet多项式混合可以检测到两种肠型,CVA、年龄、BMI、CRP、IL-6和多样性差异显著。结论:作为肠-脑通讯的一个指标,肠道微生物组分析可以通过CVA的测量来扩展,以增强我们对微生物-肠-脑-轴信号传导及其通过心理生物改变的理解。
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Cardiac vagal activity is associated with gut-microbiome patterns in women-An exploratory pilot study.

Introduction: A functional reciprocity between the gut microbiome and vagal nerve activity has been suggested, however, human studies addressing this phenomenon are limited.

Methods: Twenty-four-hour cardiac vagal activity (CVA) was assessed from 73 female participants (aged 24.5 ± 4.3 years). Additionally, stool samples were subjected to 16SrRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyse microbiome data. Additionally, inflammatory parameters (such as CRP and IL-6) were derived from serum samples.

Results: Daytime CVA correlated significantly with gut microbiota diversity (r sp = 0.254, p = 0.030), CRP (r sp = -0.348, p = 0.003), and IL-6 (r sp = -0.320, p = 0.006). When the group was divided at the median of 24 h CVA (Mdn = 1.322), the following features were more abundant in the high CVA group: Clostridia (Linear discriminant analysis effect size (LDA) = 4.195, p = 0.029), Clostridiales (LDA = 4.195, p = 0.029), Lachnospira (LDA = 3.489, p = 0.004), Ruminococcaceae (LDA = 4.073, p = 0.010), Faecalibacterium (LDA = 3.982, p = 0.042), Lactobacillales (LDA = 3.317, p = 0.029), Bacilli (LDA = 3.294, p = 0.0350), Streptococcaceae (LDA = 3.353, p = 0.006), Streptococcus (LDA = 3.332, p = 0.011). Based on Dirichlet multinomial mixtures two enterotypes could be detected, which differed significantly in CVA, age, BMI, CRP, IL-6, and diversity.

Conclusions: As an indicator of gut-brain communication, gut microbiome analysis could be extended by measurements of CVA to enhance our understanding of signalling via microbiota-gut-brain-axis and its alterations through psychobiotics.

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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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