细胞因子信号传导-1 (SOCS1)基因抑制因子多态性和启动子甲基化与COVID-19病程相关。

IF 4.9 4区 医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2023-06-01 Epub Date: 2022-11-29 DOI:10.1080/20477724.2022.2151861
Tufan Tukek, Sacide Pehlivan, Alpay Medetalibeyoglu, Istemi Serin, Yasemin Oyacı, Huzeyfe Arıcı, Naci Senkal, Mustafa Pehlivan, Ummuhan Isoglu-Alkac, Murat Kose
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引用次数: 0

摘要

细胞因子信号传导-1 (SOCS1)基因的抑制因子是位于16号染色体上的一个短序列,其功能是诱导适当的免疫反应,是干扰素(IFN)信号传导的重要生理调节因子。除了比较2019冠状病毒病(COVID-19)患者与健康对照者的整体DNA和SOCS1基因启动子甲基化状态外,本研究还验证了SOCS1 rs33989964多态性对COVID-19患者的影响。研究组纳入2020年6月至12月在我院门诊诊断为COVID-19的139例患者,对照组纳入78例健康个体。将患者的初始基因多态性与健康对照组进行比较后,形成三个独立的临床亚组。在这些临床亚组中检测SOCS1基因多态性分布和甲基化状态。与健康对照组相比,在COVID-19患者组中观察到SOCS1基因低甲基化(p = 0.001)。在分为重度感染和轻度感染两个临床亚组的患者中,重度感染患者中SOCS1基因Del/Del基因型比轻度感染患者更常见(p = 0.018)。CA/CA和CA/Del基因型患者发生严重感染的可能性是前者的0.201倍(95% CI: 0.057-0.716, p = 0.007)。具有非Del/Del基因型是防止严重感染的保护因素。SOCS1 rs33989964多态性和SOCS1基因甲基化状态在COVID-19大流行期间的影响可能对文献有重要贡献。
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The suppressor of cytokine signaling-1 (SOCS1) gene polymorphism and promoter methylation correlate with the course of COVID-19.

The suppressor of the cytokine signaling-1 (SOCS1) gene is a short sequence located on chromosome 16 that functions to induce an appropriate immune response and is an essential physiological regulator of interferon (IFN) signaling. In addition to comparing the global DNA and SOCS1 gene promoter methylation status between our patients with coronavirus disease 2019 (COVID-19) and healthy controls, this study demonstrates the effect of the SOCS1 rs33989964 polymorphism on patients with COVID-19. The study group included 139 patients diagnosed with COVID-19 in our hospital's clinics between June and December 2020, and the control group included 78 healthy individuals. After comparing the initial gene polymorphisms of the patients with the healthy control group, three separate clinical subgroups were formed. The gene polymorphism distribution and the methylation status of SOCS1 were examined in these clinical subgroups. Hypomethylation of the SOCS1 gene was observed in the COVID-19 patient group compared to the healthy control group (p = 0.001). Between the patients divided into two separate clinical subgroups, those with severe and mild infections, the Del/Del genotype of the SOCS1 gene was more common in patients with severe infection than in patients with mild infection (p = 0.018). Patients with the CA/CA and CA/Del genotypes were 0.201 times more likely to have a severe infection (95% CI: 0.057-0.716, p = 0.007). Having a non-Del/Del genotype was a protective factor against severe infection. The effect of the SOCS1 rs33989964 polymorphism and methylation status of the SOCS1 gene throughout the COVID-19 pandemic could be significant contributions to the literature.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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