脂族胺类(香叶胺、八角胺、柠檬酸AMP)共感类药物在接受过程中的安全性问题

O. Yakovlev, M. Vakhviyaynen, M. A. Judin, A. Anokhin, A. Konovalov
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引用次数: 0

摘要

用于减肥或提高成绩的运动营养可能含有精神兴奋剂脂肪胺。其中最常见的是DMAA,八磷酸腺苷和柠檬酸腺苷。上述化合物没有毒理学数据,这阻碍了它们的临床前和临床研究,也阻碍了过量治疗的最佳给药方案或算法的形成。我们确定上述药物均具有<20%的低累积度。根据这类药物的性质,疗程不应超过7天,以避免并发症和成瘾的发展。
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The problem of the course reception of sympatomimetics from the group of aliphatic amines safety (geranamine, octodrine, AMP citrate)
Sport nutrition used to reduce weight or improve performance may contain psychostimulant aliphatic amines. The most common of them are DMAA, octodrine and AMP citrate. There are no toxicometric data for above compounds, which prevents their preclinical and clinical study and the formation of optimal dosing regimens or algorithms for overdose therapy. We determined that all of the above drugs have a low degree of cumulation of <20%. Based on the properties of this class of drug, the course should not exceed 7 days in order to avoid complications and the development of addiction.
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