生理生理条件下高级AAA破裂风险分析

I. Taib, K. Osman, M. R. A. Kadir, M. H. Padzillah
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摘要

晚期动脉瘤破裂的风险是医学界和研究者非常关注的问题。数值模拟人员也对这次破裂的预测做出了贡献。在这项研究中,研究了各种生理和物理条件对破裂风险增加的影响。对于高级动脉瘤,本研究采用基于实际形态的简化动脉瘤模型。采用三维模型,对代表不同物理条件的各种流动情况进行了评价。对正常血压(NBP)和高血压(HBP)的影响进行了研究。本研究表明,在休息和运动条件下,当血流达到收缩期晚期时,观察到晚期动脉瘤患者在远端区域有漩涡形成。由于该区域墙体剪应力波动较大,这种现象将增加破裂的危险性。较低的破裂风险也观察到在近端区域与弱涡旋的存在。研究结果还表明,与正常血压在静止状态下相比,运动状态下的高血压出现血管破裂的风险大约是正常血压的两倍。
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Risk of rupture analysis for advanced level of AAA under combined physiological and physical conditions
The risk of rupture for advanced level of aneurysm is very much investigated by medical practitioners and researchers. Numerical modelers have also been contributing to the prediction of this rupture. In this study, the effect of various physiological and physical conditions to the increased of the risk rupture is investigated. This study uses simplified model of aneurysm based on actual shape for the advanced level of aneurysm. Three-dimensional model was used and various flow situations representing various physical conditions were evaluated. Both normal blood pressure (NBP) and high blood pressure (HBP) effect were studied in this case. This study shows that a person with advanced level of aneurysm is observed to have vortex formation as the flow reaches late systole, in the distal region under both resting and exercise conditions. This phenomenon will increase the risk of rupture due to the high fluctuation of wall shear stress in this area. Lower risk of rupture is also observed in the proximal area with the presence of weak vortex. The results also show that high blood pressure under exercise conditions exhibits approximately double the risk for rupture as compared to normal blood pressure under resting condition.
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