{"title":"利用聚l -丙交酯-维生素E TPGS胶束逆转乳腺癌细胞的多药耐药","authors":"P. Y. Li, P. Lai, C. Lin","doi":"10.1109/ICBPE.2009.5384064","DOIUrl":null,"url":null,"abstract":"Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size (≪ 200nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"9 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell\",\"authors\":\"P. Y. Li, P. Lai, C. Lin\",\"doi\":\"10.1109/ICBPE.2009.5384064\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size (≪ 200nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.\",\"PeriodicalId\":384086,\"journal\":{\"name\":\"2009 International Conference on Biomedical and Pharmaceutical Engineering\",\"volume\":\"9 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2009 International Conference on Biomedical and Pharmaceutical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/ICBPE.2009.5384064\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 International Conference on Biomedical and Pharmaceutical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICBPE.2009.5384064","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell
Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size (≪ 200nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.
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