一种糖酵解标记试验,用于个体化选择具有抗肿瘤活性的化合物。

L A Piruzian, E M Mikhaĭlovskiĭ
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引用次数: 0

摘要

基于文献资料对不同制剂对肿瘤细胞和正常细胞糖酵解作用的影响,提出了糖酵解分子生化标记物筛选潜在抗肿瘤药物的化学物质。肿瘤细胞具有糖酵解的特异性,这被认为是区分肿瘤细胞与正常细胞和不同组织类型肿瘤细胞的标准,也是肿瘤细胞对某种物质的选择性敏感性的标准。38种被测物质中有17种被观察到抑制肿瘤细胞糖酵解。介绍了应用糖酵解标记物检测抗肿瘤活性的化学物质。讨论了应用该标记物检测潜在抗肿瘤药物、其个体化和基因分型的可能性。
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[A glycolytic marker test for individualizing the selection of chemical compounds for antitumor activity].

Based on literature data on effects of various preparations on the glycolysis in tumor and normal cells, a glycolytic molecular biochemical marker is proposed to screen chemical substances as potential antitumor drugs. A glycolytic specificity was noted in tumor cells which was regarded as a criterion for distinction of tumor cells from normal ones and among various histotypes of tumor cells as well as for the selective sensitivity of tumor cells to a substance. 17 of 38 substances tested were observed to inhibit glycolysis in tumor cells. The testing chemical substances for an antitumor activity with application of the glycolytic marker is recommended. A possibility is discussed of applying the marker for testing potential antitumor drugs, their individualization, and genetic typing.

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