[维生素A——生长、分化和形态发生研究中的探针]。

S Koussoulakos, H J Anton
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引用次数: 0

摘要

关于维生素A的科学研究工作早在一百多年前就开始了。迄今为止积累的信息已经发表在数千篇原创论文、评论文章、专题丛书和书籍中。这些调查的总体结果可以集中在本综述的标题中。维生素A及其类似物类维生素A直接参与多种生理功能,如视力、生长、发育和分化。这些化合物在治疗几种严重皮肤病和癌症治疗中也有很好的应用。它们的活性也被广泛用于胚胎发生、致畸和致癌的研究。最近的进展归因于维甲酸的性质,这使其成为假定的第一个脊椎动物形态原的候选者。这些进展与同源盒基因的研究进展相结合,为在分子水平上阐明类维生素a的作用模式开辟了新的途径。这很容易让人推测,对类维生素a作用的基本生物学有足够的了解,可能会有益于人类的改善。
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[Vitamin A--a probe in the study of growth, differentiation and morphogenesis].

Scientific work on vitamin A research has started more than one hundred years ago. The information accumulated thus far has already been published in thousands of original papers, review articles, monographic series and books. The overall result of these investigations can be concentrated in the title of the present review. Vitamin A and its analogues, the retinoids, participate directly in several physiological functions, such as vision, growth, development and differentiation. These compounds have also found useful application in the cure of several serious dermatological diseases and in cancer therapy. Their activities are also widely exploited to study embryogenesis, teratogenesis and carcinogenesis. Recent advances ascribe to retinoic acid properties, which render it a putative candidate for the first vertebrate morphogen. These developments, in combination with progress made in the study of homeo box genes, open new ways towards elucidating the mode of action of retinoids at the molecular level. It is tempting to speculate that, understanding enough about the basic biology of retinoid action, might be beneficially exploited for the betterment of the mankind.

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