[一种识别tRNA基因相似性及其整体分类的信息方法]。

M B Chaleĭ, E V Korotkov
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引用次数: 0

摘要

基于DNA序列比较分析的信息化方法和模糊关系的概念,对EMBL-8数据库中连接氨基酸TRP和ASP的两个tRNA基因集合体提出了新的分类方案。这些分类方案以树形图的形式呈现,反映了两种聚合体中tRNA基因之间可能的进化相互关系。从两个角度分析了tRNA基因之间的进化关系:1)考虑了所有四个核苷酸的DNA序列之间的相互关系;2)考虑到DNA序列向过渡方向分化的可能的进化压力。在这两种情况下,考虑了每个基因聚集体的树图的相似性和差异性。结果表明,对DNA和RNA序列分化的进化压力的所有可能方向的分析为构建全局tRNA系统发育提供了一种新的途径。
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[An informational approach to recognizing the similarity of tRNA genes and their global classification].

Based on informational approach to the comparative analysis of DNA sequences and the conception of fuzzy relations, new classification schemes were suggested for two aggregates of tRNA genes from the EMBL-8 data bank connecting amino acids TRP and ASP. These classification schemes are presented as a dendrogram and reflect possible evolutionary interrelation between tRNA genes in both aggregates. Evolutionary interrelations between tRNA genes were analyzed from two standpoints: 1) taking into consideration the interrelation between DNA sequences by all four nucleotides; 2) taking into account possible evolutionary pressure to the divergence of DNA sequences towards transitions. The similarity and difference of dendrograms for each gene aggregate were considered in both instances. It was shown that the analysis of all possible directions of the evolutionary pressure to the divergence of DNA and RNA sequences provides a new approach to the construction of a global tRNA phylogeny.

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