[神经系统营养功能动态紊乱时肾小管细胞中的钠重吸收和醛固酮受体]。

Iu A Akimov, A A Rodionov, A I Grishchenko, Ia I Azhipa
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引用次数: 0

摘要

本文介绍了在反射性肾营养不良的不同阶段,以及在神经系统营养功能紊乱后不同时期注射心得安导致肾去神经支配的情况下,测定大鼠肾矿皮质激素受体器官功能状态的研究结果。研究表明,同时阻断坐骨神经中央端到肾脏的病理刺激传递的神经传导和体液通路,比仅阻断神经传导通路更能防止器官营养紊乱的发生,这是通过矿皮质激素受体状态测试的。决定矿皮质激素在肾小管细胞内接受的分子结构的活性似乎受到中枢神经传导和体液机制的控制。
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[Sodium reabsorption and the aldosterone receptors in the cells of the kidney tubules in a dynamic disorder of the trophic function of the nervous system].

The results are presented of investigations on determining the functional state of mineralocorticoid receptor apparatus in rat kidney at diverse stages of the reflex renal dystrophy per se and that against the background of renal denervation along with propranolol injections produced at different terms following the disturbance of nervous system trophic function. It was shown that simultaneous blockade of neuroconductory and humoral pathways of pathological stimulus transmission from central end of cut ischiatic nerve to the kidney prevents the development of trophic disturbances in the organ as tested by the state of mineralocorticoid receptors, to a more extent than the blockade of neuroconductory pathway only. The activity of molecular structures which determine the mineralocorticoid reception in cells of renal tubules seems to be controlled both by central neuroconductory and humoral mechanisms.

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