[angora-Y基因的作用位点及其与小鼠fuzzy-Y基因的相互作用]。

A S Berdaliev, B V Koniukhov
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引用次数: 0

摘要

在聚集嵌合体C57BL-goY/goY----DBA(+/+)中确定了goY突变基因的作用位点。通过表皮色素镶嵌和葡萄糖磷酸异构酶的电泳模式检测嵌合现象。在28天大的嵌合体中,浅棕色的皮毛区域交替着黑色的皮毛,短毛的条纹交替着长毛的条纹。这些不同长度和宽度的条纹从脊柱向侧腹方向延伸。长毛条拔除的毛发长度与相同年龄的goY/goY小鼠相似,而短毛条拔除的毛发长度与+/+小鼠一致。这些数据表明,goY基因作用于毛囊表皮细胞,其表达是自主的。已经确定,在双纯合子中,goY/goYfzY/fzY两种突变基因都有表达:与正常相比,毛发长度明显增加——goY基因的作用,卷曲的被毛——fzY基因的作用。在G1保护毛形成期间的goY/goYfzY/fzY小鼠中,由于fzY突变基因抑制毛发生长,观察到goY基因的不完全表达。fzY基因不抑制G2毛的生长,因此在goY/goYfzY/fzY成年小鼠中出现了goY基因的完全表达。
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[The site of the action of the angora-Y gene and its interaction with the fuzzy-Y gene in the mouse].

The site of action of the goY mutant gene was determined in the aggregation chimaeras C57BL-goY/goY----DBA (+/+). Chimerism was detected by mosaicism of coat pigmentation and electrophoretic pattern of glucose phosphate isomerase. In 28-day-old chimaeras the regions of light-brown coat alternated black coat, stripes of short hairs alternated those of long hairs. These stripes of different length and width extended from spine in lateral-ventral direction. The hairs plucked from long hairs stripes had a similar length that those of goY/goY mice of same age, but the hairs plucked from short hair stripes corresponded to the hair length of +/+ mice. These data show that the goY gene acts in epidermal cells of hair follicles and its expression is autonomous. It has been established that in double homozygotes goY/goYfzY/fzY both mutant genes are expressed: the considerable increase of hair length as compared to norm--the effect of the goY gene and curly coat--the effect of the fzY gene. In goY/goYfzY/fzY mice during the formation of G1 guard hairs the incomplete expression of the goY gene is observed that is due to the suppression of hair growth by the fzY mutant gene. The fzY gene does not suppress the growth of G2 hairs and therefore the full expression of the goY gene occurs in goY/goYfzY/fzY adult mice.

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