肥胖是否引致肺叶切除后的并发症呢?

T. Lesser
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摘要

背景:本研究的目的是评估BMI对肺肺叶切除术患者短期预后的影响。方法:这是一项在单一机构进行的回顾性临床队列研究,旨在评估接受肺切除术的肥胖患者的短期预后。比较肥胖(BMI≥30 kg/m2)和非肥胖(BMI <30 kg/m2)两个研究亚组的术中和术后参数。结果:共纳入203例患者(70例肥胖患者,133例非肥胖患者)。两个研究亚组在人口统计学、临床数据和手术入路(胸腔镜与开胸手术)方面具有可比性。肥胖患者手术时间明显延长(p = 0.048)。两组患者术中并发症发生频率差异无统计学意义(p = 0.635)。两个研究亚组术后住院时间相似(p = 0.366)。非肥胖患者的术后30天发病率较高(33.8% vs. 21.7%),但差异无统计学意义(p = 0.249)。在非肥胖患者亚组中,观察到轻度和重度术后并发症的频率更高。然而,由于临界p值(p = 0.053),研究亚组之间的差异无统计学意义。肥胖和非肥胖患者术后30天死亡率相当(p = 0.167)。结论:肥胖不会增加肺肺叶切除术后术中及术后并发症的发生率和严重程度。肥胖患者的预后略好,这表明肥胖悖论可能是接受肺切除术患者的现实。
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Ist die Adipositas ein Risikofaktor für postoperative Komplikationen nach Lungenlappenresektion?
Background: The aim of the present study was to evaluate the impact of BMI on the short-term outcomes of patients undergoing lung lobectomy. Methods: This was a retrospective clinical cohort study conducted in a single institution to assess the short-term outcomes of obese patients undergoing lung resection. Intraoperative and postoperative parameters were compared between the two study subgroups: obese (BMI ≥30 kg/m2) and non-obese patients (BMI <30 kg/m2). Results: In total, 203 patients were enrolled in the study (70 obese and 133 non-obese patients). Both study subgroups were comparable with regards to demographics, clinical data and surgical approach (thoracoscopy vs. thoracotomy). The surgery time was significantly longer in obese patients (p = 0.048). There was no difference in the frequency of intraoperative complications between the study subgroups (p = 0.635). The postoperative hospital stay was similar in both study subgroups (p = 0.366). A 30-day postoperative morbidity was higher in a subgroup of non-obese patients (33.8% vs. 21.7%), but the difference was not significant (p = 0.249). In the subgroup of non-obese patients, a higher frequency of mild and severe postoperative complications was observed. However, the differences between the study subgroups were not statistically significant due to the borderline p-value (p = 0.053). The 30-day postoperative mortality was comparable between obese and non-obese patients (p = 0.167). Conclusions: Obesity does not increase the incidence and severity of intraoperative and postoperative complications after lung lobectomy. Slightly better outcomes in obese patients indicate that obesity paradox might be a reality in patients undergoing lung resection.
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