用于低流量药物输送系统的不依赖压力的压电阀微型泵

A. Geipel, A. Doll, F. Goldschmidtboing, P. Jantscheff, N. Esser, U. Massing, P. Woias
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引用次数: 27

摘要

我们首次提出了一种新型的微泵设计,它可以在药物输送系统所需的低流量范围内实现不依赖背压的高达20 kPa的流量。我们的概念,基于两个压电驱动隔膜,允许在1 - 50 μ l/min范围内的精确剂量,具有自由可编程的释放配置文件,并且与3执行器蠕动微泵相比,提供了最大限度地减少芯片尺寸和功耗的潜力。冲程体积在50 - 200 nl之间可调,通过电压控制实现高分辨率的体积计量。在低于2hz的相关频率范围内,流量与频率成正比。我们的设计还擅长于其相对简单和坚固的2层制造工艺。
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Pressure-Independent Micropump with Piezoelectric Valves for Low Flow Drug Delivery Systems
We present - for the first time - a novel design of a micropump which enables a backpressure-independent flow rate up to 20 kPa within the low flow regime required for drug delivery systems. Our concept, based on two piezoelectrically actuated diaphragms, allows an accurate dosing in the range of 1 - 50 µ l/min with freely programmable release profiles and offers the potential to minimize chip size and power consumption in comparison to 3-actuator peristaltic micropumps. The stroke volume is adjustable between 50 - 200 nl by means of voltage control which enables a high resolution volumetric dosing. Within the relevant frequency range below 2 Hz the flow rate is proportional to the frequency. Our design also excels in its comparably simple and robust 2-layer fabrication process.
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