{"title":"开启谜题:甘露醇溶脓菌败血症-临床之旅,多维调查和范式转换研究见解","authors":"Nabeela Al-Abdullah, Amir Yousef Neyazi","doi":"10.13005/bbra/3138","DOIUrl":null,"url":null,"abstract":"This case report focuses on a patient from Saudi Arabia who developed Ralstonia mannitolilytica septicemia. We present the clinical presentation, docking, simulation, and bioinformatics studies conducted to gain insights into the infectious strain. The patient initially presented with fever, chills, and septic shock, and showed decreased white blood cell and platelet counts with elevated inflammation markers. Treatment with Tazocin resulted in a favorable response. The infectious strain exhibited prolonged growth in distilled water and showed distinct genetic characteristics. Our multidisciplinary approach revealed insights into virulence factors and potential drug targets. The study contributes to understanding R. mannitolilytica septicemia and emphasizes the importance of prompt diagnosis and appropriate antimicrobial therapy. Further research is needed to explore pathogenesis, transmission dynamics, and optimal management strategies for R. mannitolilytica infections.","PeriodicalId":9032,"journal":{"name":"Biosciences, Biotechnology Research Asia","volume":"36 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inauguration the Enigma: Ralstonia mannitolilytica Septicemia - Clinical Journey, Multidimensional Investigation, and Paradigm- Shifting Research Insights\",\"authors\":\"Nabeela Al-Abdullah, Amir Yousef Neyazi\",\"doi\":\"10.13005/bbra/3138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This case report focuses on a patient from Saudi Arabia who developed Ralstonia mannitolilytica septicemia. We present the clinical presentation, docking, simulation, and bioinformatics studies conducted to gain insights into the infectious strain. The patient initially presented with fever, chills, and septic shock, and showed decreased white blood cell and platelet counts with elevated inflammation markers. Treatment with Tazocin resulted in a favorable response. The infectious strain exhibited prolonged growth in distilled water and showed distinct genetic characteristics. Our multidisciplinary approach revealed insights into virulence factors and potential drug targets. The study contributes to understanding R. mannitolilytica septicemia and emphasizes the importance of prompt diagnosis and appropriate antimicrobial therapy. Further research is needed to explore pathogenesis, transmission dynamics, and optimal management strategies for R. mannitolilytica infections.\",\"PeriodicalId\":9032,\"journal\":{\"name\":\"Biosciences, Biotechnology Research Asia\",\"volume\":\"36 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosciences, Biotechnology Research Asia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13005/bbra/3138\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosciences, Biotechnology Research Asia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13005/bbra/3138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Inauguration the Enigma: Ralstonia mannitolilytica Septicemia - Clinical Journey, Multidimensional Investigation, and Paradigm- Shifting Research Insights
This case report focuses on a patient from Saudi Arabia who developed Ralstonia mannitolilytica septicemia. We present the clinical presentation, docking, simulation, and bioinformatics studies conducted to gain insights into the infectious strain. The patient initially presented with fever, chills, and septic shock, and showed decreased white blood cell and platelet counts with elevated inflammation markers. Treatment with Tazocin resulted in a favorable response. The infectious strain exhibited prolonged growth in distilled water and showed distinct genetic characteristics. Our multidisciplinary approach revealed insights into virulence factors and potential drug targets. The study contributes to understanding R. mannitolilytica septicemia and emphasizes the importance of prompt diagnosis and appropriate antimicrobial therapy. Further research is needed to explore pathogenesis, transmission dynamics, and optimal management strategies for R. mannitolilytica infections.