开启谜题:甘露醇溶脓菌败血症-临床之旅,多维调查和范式转换研究见解

Nabeela Al-Abdullah, Amir Yousef Neyazi
{"title":"开启谜题:甘露醇溶脓菌败血症-临床之旅,多维调查和范式转换研究见解","authors":"Nabeela Al-Abdullah, Amir Yousef Neyazi","doi":"10.13005/bbra/3138","DOIUrl":null,"url":null,"abstract":"This case report focuses on a patient from Saudi Arabia who developed Ralstonia mannitolilytica septicemia. We present the clinical presentation, docking, simulation, and bioinformatics studies conducted to gain insights into the infectious strain. The patient initially presented with fever, chills, and septic shock, and showed decreased white blood cell and platelet counts with elevated inflammation markers. Treatment with Tazocin resulted in a favorable response. The infectious strain exhibited prolonged growth in distilled water and showed distinct genetic characteristics. Our multidisciplinary approach revealed insights into virulence factors and potential drug targets. The study contributes to understanding R. mannitolilytica septicemia and emphasizes the importance of prompt diagnosis and appropriate antimicrobial therapy. Further research is needed to explore pathogenesis, transmission dynamics, and optimal management strategies for R. mannitolilytica infections.","PeriodicalId":9032,"journal":{"name":"Biosciences, Biotechnology Research Asia","volume":"36 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inauguration the Enigma: Ralstonia mannitolilytica Septicemia - Clinical Journey, Multidimensional Investigation, and Paradigm- Shifting Research Insights\",\"authors\":\"Nabeela Al-Abdullah, Amir Yousef Neyazi\",\"doi\":\"10.13005/bbra/3138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This case report focuses on a patient from Saudi Arabia who developed Ralstonia mannitolilytica septicemia. We present the clinical presentation, docking, simulation, and bioinformatics studies conducted to gain insights into the infectious strain. The patient initially presented with fever, chills, and septic shock, and showed decreased white blood cell and platelet counts with elevated inflammation markers. Treatment with Tazocin resulted in a favorable response. The infectious strain exhibited prolonged growth in distilled water and showed distinct genetic characteristics. Our multidisciplinary approach revealed insights into virulence factors and potential drug targets. The study contributes to understanding R. mannitolilytica septicemia and emphasizes the importance of prompt diagnosis and appropriate antimicrobial therapy. Further research is needed to explore pathogenesis, transmission dynamics, and optimal management strategies for R. mannitolilytica infections.\",\"PeriodicalId\":9032,\"journal\":{\"name\":\"Biosciences, Biotechnology Research Asia\",\"volume\":\"36 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-10-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosciences, Biotechnology Research Asia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.13005/bbra/3138\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosciences, Biotechnology Research Asia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13005/bbra/3138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

本病例报告的重点是来自沙特阿拉伯的患者谁开发的Ralstonia甘露醇溶脓毒症。我们介绍了临床表现、对接、模拟和生物信息学研究,以深入了解感染菌株。患者最初表现为发热、寒战和感染性休克,白细胞和血小板计数减少,炎症标志物升高。他唑辛治疗效果良好。传染菌株在蒸馏水中生长时间长,遗传特征明显。我们的多学科方法揭示了毒力因素和潜在药物靶点的见解。该研究有助于了解甘露醇溶脓杆菌败血症,并强调及时诊断和适当抗菌治疗的重要性。甘露醇溶乳杆菌感染的发病机制、传播动力学和最佳治疗策略有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Inauguration the Enigma: Ralstonia mannitolilytica Septicemia - Clinical Journey, Multidimensional Investigation, and Paradigm- Shifting Research Insights
This case report focuses on a patient from Saudi Arabia who developed Ralstonia mannitolilytica septicemia. We present the clinical presentation, docking, simulation, and bioinformatics studies conducted to gain insights into the infectious strain. The patient initially presented with fever, chills, and septic shock, and showed decreased white blood cell and platelet counts with elevated inflammation markers. Treatment with Tazocin resulted in a favorable response. The infectious strain exhibited prolonged growth in distilled water and showed distinct genetic characteristics. Our multidisciplinary approach revealed insights into virulence factors and potential drug targets. The study contributes to understanding R. mannitolilytica septicemia and emphasizes the importance of prompt diagnosis and appropriate antimicrobial therapy. Further research is needed to explore pathogenesis, transmission dynamics, and optimal management strategies for R. mannitolilytica infections.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Immobilization of Bee Pollen Extract on Polyethylene Terephthalate (PET) Fabric for Wound Dressing Inauguration the Enigma: Ralstonia mannitolilytica Septicemia - Clinical Journey, Multidimensional Investigation, and Paradigm- Shifting Research Insights Identification and Assessment of Non-Genetic Factors Contributing to Nephrolithiasis (Kidney Stone) in the Jammu Region Screening of Phytochemicals from Derris indica for Antimycobacterial Potential using Molecular Docking Analysis A Study on Plant Diversity of Iringole Kavu, Ernakulam, Kerala State
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1