肯尼亚西部一些药用植物的抗疟原虫和细胞毒活性

Daniel Wekesa, Fidelis Mambo, Erick Barasa, Kevin Soita, Abdiaziz Ali Gosar, Nicholas Kitungulu, Nathan Shaviya
{"title":"肯尼亚西部一些药用植物的抗疟原虫和细胞毒活性","authors":"Daniel Wekesa, Fidelis Mambo, Erick Barasa, Kevin Soita, Abdiaziz Ali Gosar, Nicholas Kitungulu, Nathan Shaviya","doi":"10.31254/phyto.2023.12402","DOIUrl":null,"url":null,"abstract":"Malaria is a potentially lethal illness that is transmitted through the bite of mosquitoes and is caused by a parasitic organism. Individuals who are pregnant, small children, and the elderly are considered to be especially susceptible to the condition. The presently accessible antimalarial medications are associated with adverse effects and substantial expenses, particularly in regions with little financial resources. Medicinal plants present a viable option owing to their reduced incidence of adverse effects, decreased financial burden, and convenient availability. Nevertheless, the existing body of research pertaining to the utilization of medicinal plants for the treatment of malaria is somewhat restricted. The objective of this study was to investigate the cytotoxic and antiplasmodial characteristics of various medicinal plants found in Kakamega County, located in Western Kenya. In vitro studies were conducted using organic and aqueous extracts derived from the plants. The extracts were used to assess both chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Additionally, an evaluation was conducted to determine the safety and cytotoxicity of the plant extracts. The plant extracts obtained from dichloromethane exhibited the lowest yield, whereas the water extracts yielded the highest proportion. Plants belonging to the Leguminosae family, namely Senna didmobotrya and Senna occidentalis, exhibited the most substantial productivity when subjected to water and methanol solvents. Several plant extracts shown significant antiplasmodial action against both the chloroquine-sensitive and chloroquine-resistant strains of the malaria parasite. A number of extracts had a moderate level of antiplasmodial action, but a small subset exhibited poor or negligible activity. Of the three examined extract types (water, methanol, and dichloromethane), it was shown that the methanol extracts exhibited the greatest prevalence of plants with significant antiplasmodial activity against the chloroquine-sensitive strain. The majority of the methanol extracts exhibited moderate action against both strains, although a minority shown low or no activity. The extracts of dichloromethane also exhibited a variety of antiplasmodial properties. In general, the study unveiled the therapeutic potential of medicinal plants found in Kakamega County, located in Western Kenya, for the treatment of malaria. The efficacy of these plants in inhibiting the growth of both chloroquine-sensitive and chloroquine-resistant strains of the malaria parasite was demonstrated. The results of this study offer significant insights for stakeholders who are interested in investigating the potential of herbal remedies as an alternate strategy for the treatment of malaria.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiplasmodial and cytotoxic activities of selected medicinal plants in Western Kenya\",\"authors\":\"Daniel Wekesa, Fidelis Mambo, Erick Barasa, Kevin Soita, Abdiaziz Ali Gosar, Nicholas Kitungulu, Nathan Shaviya\",\"doi\":\"10.31254/phyto.2023.12402\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Malaria is a potentially lethal illness that is transmitted through the bite of mosquitoes and is caused by a parasitic organism. Individuals who are pregnant, small children, and the elderly are considered to be especially susceptible to the condition. The presently accessible antimalarial medications are associated with adverse effects and substantial expenses, particularly in regions with little financial resources. Medicinal plants present a viable option owing to their reduced incidence of adverse effects, decreased financial burden, and convenient availability. Nevertheless, the existing body of research pertaining to the utilization of medicinal plants for the treatment of malaria is somewhat restricted. The objective of this study was to investigate the cytotoxic and antiplasmodial characteristics of various medicinal plants found in Kakamega County, located in Western Kenya. In vitro studies were conducted using organic and aqueous extracts derived from the plants. The extracts were used to assess both chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Additionally, an evaluation was conducted to determine the safety and cytotoxicity of the plant extracts. The plant extracts obtained from dichloromethane exhibited the lowest yield, whereas the water extracts yielded the highest proportion. Plants belonging to the Leguminosae family, namely Senna didmobotrya and Senna occidentalis, exhibited the most substantial productivity when subjected to water and methanol solvents. Several plant extracts shown significant antiplasmodial action against both the chloroquine-sensitive and chloroquine-resistant strains of the malaria parasite. A number of extracts had a moderate level of antiplasmodial action, but a small subset exhibited poor or negligible activity. Of the three examined extract types (water, methanol, and dichloromethane), it was shown that the methanol extracts exhibited the greatest prevalence of plants with significant antiplasmodial activity against the chloroquine-sensitive strain. The majority of the methanol extracts exhibited moderate action against both strains, although a minority shown low or no activity. The extracts of dichloromethane also exhibited a variety of antiplasmodial properties. In general, the study unveiled the therapeutic potential of medicinal plants found in Kakamega County, located in Western Kenya, for the treatment of malaria. The efficacy of these plants in inhibiting the growth of both chloroquine-sensitive and chloroquine-resistant strains of the malaria parasite was demonstrated. The results of this study offer significant insights for stakeholders who are interested in investigating the potential of herbal remedies as an alternate strategy for the treatment of malaria.\",\"PeriodicalId\":22851,\"journal\":{\"name\":\"The Journal of Phytopharmacology\",\"volume\":\"62 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Phytopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31254/phyto.2023.12402\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Phytopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31254/phyto.2023.12402","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

疟疾是一种潜在的致命疾病,由一种寄生生物引起,通过蚊子叮咬传播。孕妇、幼儿和老年人被认为特别容易受到这种情况的影响。目前可获得的抗疟疾药物与不良反应和大量费用有关,特别是在财政资源很少的地区。药用植物是一种可行的选择,因为它们减少了不良反应的发生率,减轻了经济负担,而且易于获得。然而,现有的关于利用药用植物治疗疟疾的研究在某种程度上受到限制。本研究的目的是调查在肯尼亚西部卡卡梅加县发现的各种药用植物的细胞毒性和抗疟原虫特性。体外研究使用从植物中提取的有机和水提取物进行。该提取物用于恶性疟原虫氯喹敏感(3D7)和耐氯喹(W2)菌株的鉴定。此外,还进行了评估以确定植物提取物的安全性和细胞毒性。从二氯甲烷中提取的植物提取物产率最低,而水提取物产率最高。豆科植物,即塞纳(Senna didmobotrya)和西塞纳(Senna occidentalis),在水和甲醇溶剂中表现出最显著的生产力。几种植物提取物对氯喹敏感型和耐氯喹型疟原虫均有明显的抗疟原虫作用。许多提取物具有中等水平的抗疟原虫作用,但一小部分表现出较差或可忽略不计的活性。在三种提取类型(水、甲醇和二氯甲烷)中,甲醇提取物显示出对氯喹敏感菌株具有显著抗疟原虫活性的植物最普遍。大多数甲醇提取物对这两种菌株表现出中等的作用,尽管少数表现出低活性或没有活性。二氯甲烷提取物也表现出多种抗疟原虫特性。总的来说,这项研究揭示了在肯尼亚西部Kakamega县发现的治疗疟疾的药用植物的治疗潜力。这些植物对氯喹敏感型和抗氯喹型疟原虫的生长均有抑制作用。这项研究的结果为有兴趣调查草药作为治疗疟疾的替代策略的潜力的利益相关者提供了重要的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Antiplasmodial and cytotoxic activities of selected medicinal plants in Western Kenya
Malaria is a potentially lethal illness that is transmitted through the bite of mosquitoes and is caused by a parasitic organism. Individuals who are pregnant, small children, and the elderly are considered to be especially susceptible to the condition. The presently accessible antimalarial medications are associated with adverse effects and substantial expenses, particularly in regions with little financial resources. Medicinal plants present a viable option owing to their reduced incidence of adverse effects, decreased financial burden, and convenient availability. Nevertheless, the existing body of research pertaining to the utilization of medicinal plants for the treatment of malaria is somewhat restricted. The objective of this study was to investigate the cytotoxic and antiplasmodial characteristics of various medicinal plants found in Kakamega County, located in Western Kenya. In vitro studies were conducted using organic and aqueous extracts derived from the plants. The extracts were used to assess both chloroquine-sensitive (3D7) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Additionally, an evaluation was conducted to determine the safety and cytotoxicity of the plant extracts. The plant extracts obtained from dichloromethane exhibited the lowest yield, whereas the water extracts yielded the highest proportion. Plants belonging to the Leguminosae family, namely Senna didmobotrya and Senna occidentalis, exhibited the most substantial productivity when subjected to water and methanol solvents. Several plant extracts shown significant antiplasmodial action against both the chloroquine-sensitive and chloroquine-resistant strains of the malaria parasite. A number of extracts had a moderate level of antiplasmodial action, but a small subset exhibited poor or negligible activity. Of the three examined extract types (water, methanol, and dichloromethane), it was shown that the methanol extracts exhibited the greatest prevalence of plants with significant antiplasmodial activity against the chloroquine-sensitive strain. The majority of the methanol extracts exhibited moderate action against both strains, although a minority shown low or no activity. The extracts of dichloromethane also exhibited a variety of antiplasmodial properties. In general, the study unveiled the therapeutic potential of medicinal plants found in Kakamega County, located in Western Kenya, for the treatment of malaria. The efficacy of these plants in inhibiting the growth of both chloroquine-sensitive and chloroquine-resistant strains of the malaria parasite was demonstrated. The results of this study offer significant insights for stakeholders who are interested in investigating the potential of herbal remedies as an alternate strategy for the treatment of malaria.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Comparison and Efficacy Study of In-house Developed Formulation of Fumaria indica (Pitpapra) Against Expensive Market Alternative Dracaena trifasciata (Prain) Mabb. – Traditional use, pharmacognosy, phytochemistry and pharmacology: A comprehensive review Anti-inflammatory Effects of Carissa spiranum Mediated via Attenuation of Leucocyte Migration Aqueous extract of Alstonia boonei De Wild (Apocynaceae) alleviates bone metabolism disorders induced by oxidised palm oil and sucrose supplementation in rats Evaluation of Immunomodulatory Activities of Clove Powder in Broiler
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1