Mengfan Ding, Bowen Li, Haiqin Chen, Dong Liang, R Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen, Bo Yang
{"title":"人母乳来源的长双歧杆菌亚种 CCFM1269 通过 PI3K/AKT 通路调节 GH/IGF 轴的骨形成。","authors":"Mengfan Ding, Bowen Li, Haiqin Chen, Dong Liang, R Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen, Bo Yang","doi":"10.1080/19490976.2023.2290344","DOIUrl":null,"url":null,"abstract":"<p><p><i>Bifidobacterium longum</i> subsp. <i>infantis</i> is a prevalent member of the gut microbiota of breastfed infants. In this study, the effects of human breastmilk-derived <i>B.longum</i> subsp. <i>infantis</i> CCFM1269 on bone formation in developing BALB/c mice were investigated. Newborn female and male mice were assigned to control group (administered saline), CCFM11269 group (administered <i>B. longum</i> subsp. <i>infantis</i> CCFM1269, 1 × 10<sub>9</sub> CFU/mouse/day) and I5TI group (administered <i>B. longum</i> subsp. <i>infantis</i> I5TI, 1 × 10<sub>9</sub> CFU/mouse/day) from 1-week-old to 3-, 4- and 5-week old. <i>B. longum</i> subsp. <i>infantis</i> I5TI served as a negative control in this study. The results demonstrated that <i>B. longum</i> subsp. <i>infantis</i> CCFM1269 promoted bone formation in growing mice by modulating the composition of the gut microbiota and metabolites. The expression of genes and proteins in the PI3K/AKT pathway was stimulated by <i>B. longum</i> subsp. <i>infantis</i> CCFM1269 through the GH/IGF-1 axis in growing mice. This finding suggests <i>B. longum</i> subsp. <i>infantis</i> CCFM1269 may be useful for modulating bone metabolism during growth.</p>","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":null,"pages":null},"PeriodicalIF":12.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761167/pdf/","citationCount":"0","resultStr":"{\"title\":\"Human breastmilk-derived <i>Bifidobacterium longum</i> subsp. <i>infantis</i> CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway.\",\"authors\":\"Mengfan Ding, Bowen Li, Haiqin Chen, Dong Liang, R Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen, Bo Yang\",\"doi\":\"10.1080/19490976.2023.2290344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Bifidobacterium longum</i> subsp. <i>infantis</i> is a prevalent member of the gut microbiota of breastfed infants. In this study, the effects of human breastmilk-derived <i>B.longum</i> subsp. <i>infantis</i> CCFM1269 on bone formation in developing BALB/c mice were investigated. Newborn female and male mice were assigned to control group (administered saline), CCFM11269 group (administered <i>B. longum</i> subsp. <i>infantis</i> CCFM1269, 1 × 10<sub>9</sub> CFU/mouse/day) and I5TI group (administered <i>B. longum</i> subsp. <i>infantis</i> I5TI, 1 × 10<sub>9</sub> CFU/mouse/day) from 1-week-old to 3-, 4- and 5-week old. <i>B. longum</i> subsp. <i>infantis</i> I5TI served as a negative control in this study. The results demonstrated that <i>B. longum</i> subsp. <i>infantis</i> CCFM1269 promoted bone formation in growing mice by modulating the composition of the gut microbiota and metabolites. The expression of genes and proteins in the PI3K/AKT pathway was stimulated by <i>B. longum</i> subsp. <i>infantis</i> CCFM1269 through the GH/IGF-1 axis in growing mice. This finding suggests <i>B. longum</i> subsp. <i>infantis</i> CCFM1269 may be useful for modulating bone metabolism during growth.</p>\",\"PeriodicalId\":12909,\"journal\":{\"name\":\"Gut Microbes\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":12.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761167/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gut Microbes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/19490976.2023.2290344\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut Microbes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19490976.2023.2290344","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway.
Bifidobacterium longum subsp. infantis is a prevalent member of the gut microbiota of breastfed infants. In this study, the effects of human breastmilk-derived B.longum subsp. infantis CCFM1269 on bone formation in developing BALB/c mice were investigated. Newborn female and male mice were assigned to control group (administered saline), CCFM11269 group (administered B. longum subsp. infantis CCFM1269, 1 × 109 CFU/mouse/day) and I5TI group (administered B. longum subsp. infantis I5TI, 1 × 109 CFU/mouse/day) from 1-week-old to 3-, 4- and 5-week old. B. longum subsp. infantis I5TI served as a negative control in this study. The results demonstrated that B. longum subsp. infantis CCFM1269 promoted bone formation in growing mice by modulating the composition of the gut microbiota and metabolites. The expression of genes and proteins in the PI3K/AKT pathway was stimulated by B. longum subsp. infantis CCFM1269 through the GH/IGF-1 axis in growing mice. This finding suggests B. longum subsp. infantis CCFM1269 may be useful for modulating bone metabolism during growth.
期刊介绍：
The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more.
Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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