诊断节肢动物传播的黄病毒:作为生物标志物的非结构蛋白1(NS1)。

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-07-01 Epub Date: 2023-12-21 DOI:10.1016/j.tim.2023.11.016
Martina Ceconi, Kevin K Ariën, Peter Delputte
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引用次数: 0

摘要

近几十年来,欧洲出现的危害人类健康的黄病毒急剧增加,气候变化的影响更是雪上加霜--气候变化使得这些病毒的传播媒介扩展到了新的地区。西尼罗河病毒(WNV)、乌苏图病毒(USUV)和蜱传脑炎病毒(TBEV)的共同传播对欧洲大陆构成了威胁,而难以获得早期和有鉴别力的感染诊断使情况变得更加复杂。此外,日本脑炎病毒(JEV)等非流行性病原体的传入也使准确诊断变得更加复杂。目前黄病毒诊断主要基于 RT-PCR 和病毒特异性抗体检测。然而,这两种技术都存在局限性,因此有必要开发新的检测方法,以提供早期、快速、低成本和有鉴别力的病毒感染诊断。在追求理想诊断方法的过程中,黄病毒非结构蛋白1(NS1)是开发基于抗原本身和针对它产生的抗体的诊断方法的绝佳目标。本综述介绍了这种基于 NS1 的诊断方法的潜力,重点是在欧洲共同流行的黄病毒的应用。
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Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker.

In recent decades, the presence of flaviviruses of concern for human health in Europe has drastically increased,exacerbated by the effects of climate change - which has allowed the vectors of these viruses to expand into new territories. Co-circulation of West Nile virus (WNV), Usutu virus (USUV), and tick-borne encephalitis virus (TBEV) represents a threat to the European continent, and this is further complicated by the difficulty of obtaining an early and discriminating diagnosis of infection. Moreover, the possibility of introducing non-endemic pathogens, such as Japanese encephalitis virus (JEV), further complicates accurate diagnosis. Current flavivirus diagnosis is based mainly on RT-PCR and detection of virus-specific antibodies. Yet, both techniques suffer from limitations, and the development of new assays that can provide an early, rapid, low-cost, and discriminating diagnosis of viral infection is warranted. In the pursuit of ideal diagnostic assays, flavivirus non-structural protein 1 (NS1) serves as an excellent target for developing diagnostic assays based on both the antigen itself and the antibodies produced against it. This review describes the potential of such NS1-based diagnostic methods, focusing on the application of flaviviruses that co-circulate in Europe.

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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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