Yao Gong, Lili Zou, Jang Min Park, Kai You, Xiang Yi, Bin Li
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Plane-symmetric co-flow capillary for the generation of monodisperse droplets
This study proposes a novel co-flow capillary microfluidic device that can generate highly monodisperse droplets and polymeric microspheres. The device mainly consists of two self-aligning special-shaped polymeric capillaries. The outer capillary features a gradually contracting and expanding geometry, and the inner has an elliptical cross section at the end. The elliptical nozzle of the inner capillary fits into the contraction region of the outer capillary, and so assembled device, namely a plane-symmetric co-flow capillary, benefits from the self-alignment of the capillaries. The design and manufacturing process of the device are outlined, including a discussion on how the processing conditions affect the capillary geometry. Subsequently, the proposed device is used for droplet generation tests, and the diameter distribution of generated droplets and their influencing factors are investigated. The droplet generation mechanism with the elliptical nozzle is discussed with the help of modeling and simulation. Furthermore, monodisperse porous polymeric microspheres are fabricated using the proposed device, and their porous features are characterized. The results show that the proposed device can produce monodisperse droplets with a mean diameter of a few hundred micrometers and a coefficient of variance (CV) of less than 1%, reflecting the stability of the device. Additionally, porous polymeric microspheres could be successfully produced, and the CV of the size distribution is only around 1%.
期刊介绍:
Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include:
1.000 Fundamental principles of micro- and nanoscale phenomena like,
flow, mass transport and reactions
3.000 Theoretical models and numerical simulation with experimental and/or analytical proof
4.000 Novel measurement & characterization technologies
5.000 Devices (actuators and sensors)
6.000 New unit-operations for dedicated microfluidic platforms
7.000 Lab-on-a-Chip applications
8.000 Microfabrication technologies and materials
Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).