用于生成单分散液滴的平面对称共流毛细管

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2023-12-29 DOI:10.1007/s10404-023-02703-x
Yao Gong, Lili Zou, Jang Min Park, Kai You, Xiang Yi, Bin Li
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引用次数: 0

摘要

本研究提出了一种新型共流毛细管微流体装置,可产生高度单分散的液滴和聚合物微球。该装置主要由两个自对准的特殊形状聚合物毛细管组成。外层毛细管的几何形状是逐渐收缩和膨胀的,内层毛细管的末端是椭圆形截面。内侧毛细管的椭圆形喷嘴与外侧毛细管的收缩区域相吻合,这样组装起来的装置,即平面对称的共流毛细管,得益于毛细管的自对准。本文概述了该装置的设计和制造过程,包括对加工条件如何影响毛细管几何形状的讨论。随后,利用所提出的装置进行了液滴生成测试,并研究了生成液滴的直径分布及其影响因素。在建模和模拟的帮助下,讨论了椭圆形喷嘴的液滴生成机制。此外,还利用所提出的装置制造了单分散多孔聚合物微球,并对其多孔特征进行了表征。结果表明,所提出的装置可以制造出平均直径为几百微米的单分散液滴,方差系数(CV)小于 1%,这反映了该装置的稳定性。此外,还能成功制备多孔聚合物微球,其尺寸分布的 CV 值仅为 1%左右。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Plane-symmetric co-flow capillary for the generation of monodisperse droplets

This study proposes a novel co-flow capillary microfluidic device that can generate highly monodisperse droplets and polymeric microspheres. The device mainly consists of two self-aligning special-shaped polymeric capillaries. The outer capillary features a gradually contracting and expanding geometry, and the inner has an elliptical cross section at the end. The elliptical nozzle of the inner capillary fits into the contraction region of the outer capillary, and so assembled device, namely a plane-symmetric co-flow capillary, benefits from the self-alignment of the capillaries. The design and manufacturing process of the device are outlined, including a discussion on how the processing conditions affect the capillary geometry. Subsequently, the proposed device is used for droplet generation tests, and the diameter distribution of generated droplets and their influencing factors are investigated. The droplet generation mechanism with the elliptical nozzle is discussed with the help of modeling and simulation. Furthermore, monodisperse porous polymeric microspheres are fabricated using the proposed device, and their porous features are characterized. The results show that the proposed device can produce monodisperse droplets with a mean diameter of a few hundred micrometers and a coefficient of variance (CV) of less than 1%, reflecting the stability of the device. Additionally, porous polymeric microspheres could be successfully produced, and the CV of the size distribution is only around 1%.

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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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