关于使用多针电极对肺和肾肿瘤进行射频消融(含纳米粒子和不含纳米粒子)的研究

Md. Ezaz Ahammed, Mrunal Swaroop Peravali, Santosh S. Naik, Ajay Kumar Yadav, T. Laxminidhi
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摘要

射频消融是治疗肝、肺和肾恶性肿瘤的一种替代方法。本研究采用有限元分析方法研究纳米粒子对射频消融(RFA)过程中时间和空间温度分布的影响。建立的三维热电有限元模型包括一个多针射频电极(九针,展开达 2 厘米)和一个 50 立方毫米的立方体肿瘤。在 10 分钟消融时间的温控模式(95°C)下进行了数值模拟。使用多锥形电极对不同的组织(即肺部和肾部)进行了研究,包括使用纳米粒子和不使用纳米粒子。结果表明,加入 6% 纳米粒子时,纳米粒子可提高热传导率并缩短消融时间达 13%。研究发现,在纳米粒子的辅助下,空间温度分布变得均匀。
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Study On Radiofrequency Ablation of Lung and Kidney Tumors with and Without Nanoparticles Using Multi-tined Electrode
Radiofrequency ablation is an alternative method for the cure of malign tumors in the liver, lung, and kidney. In the present work, FEM analysis is conducted to study the effect of nanoparticles on the temporal and spatial temperature distribution during radiofrequency ablation (RFA). Three dimensional thermoelectrically FEM model consisting of a multi-tined radiofrequency electrode (nine-tine, deployed up to 2 cm) and a cubical tumor of size 50 mm3 is developed. Numerical simulation is carried out under the temperature-controlled mode (95°C) with 10 minutes ablation time. A study using multi-tined electrodes is carried out on different tissues i.e., lung and kidney, with and without nanoparticles. Results show that the nanoparticles increase the heat conduction rate and decrease the ablation time up to 13% for the inclusion of 6% nanoparticles. It has been found that the spatial temperature distribution becomes uniform with nanoparticle assistance.
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