模拟肿瘤微环境的复杂性:三维肿瘤球体是一种不断发展的工具。

IF 9 2区 医学 Q1 CELL BIOLOGY Journal of Biomedical Science Pub Date : 2024-01-23 DOI:10.1186/s12929-024-00997-9
Daniel B Rodrigues, Rui L Reis, Rogério P Pirraco
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引用次数: 0

摘要

癌症仍然是社会的沉重负担,虽然新型和更有效疗法的开发速度正在加快,但却缺乏能忠实模拟肿瘤微环境的测试平台。随着动物模型向更复杂的体外三维系统的明显转变,球形体成为这方面的有力选择。经过多年的发展,球基模型已能更好地再现肿瘤相关细胞外基质(ECM)中观察到的生物力学线索,以及以细胞-细胞和细胞-ECM方式发生的细胞相互作用。在此,我们总结了推动肿瘤发生、发展和侵袭的一些关键细胞相互作用,以及目前该领域使用的三维球形模型是如何成功再现这些相互作用的。最后,我们将对该领域的未来进展以及这些进展将如何塑造球形三维模型与肿瘤建模的相关性进行推测。
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Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool.

Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell-cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling.

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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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