胶质瘤神经认知缺陷的分子决定因素:基于 2021 年世界卫生组织分类。

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Neuroscience Pub Date : 2024-02-05 DOI:10.1007/s12031-023-02173-4
Kun Zhang, Tianrui Yang, Yu Xia, Xiaopeng Guo, Wenlin Chen, Lijun Wang, Junlin Li, Jiaming Wu, Zhiyuan Xiao, Xin Zhang, Wenwen Jiang, Dongrui Xu, Siying Guo, Yaning Wang, Yixin Shi, Delin Liu, Yilin Li, Yuekun Wang, Hao Xing, Tingyu Liang, Pei Niu, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Huanzhang Li, Yi Zhang, Wenbin Ma, Yu Wang
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引用次数: 0

摘要

认知障碍是弥漫性胶质瘤患者的常见特征。本研究旨在研究术前认知功能与临床及分子因素之间的关系,首先基于世界卫生组织2021年更新的中枢神经系统肿瘤分类。共有110名弥漫性胶质瘤患者接受了术前认知评估,评估采用的是迷你精神状态检查和蒙特利尔认知评估。研究人员从病历中收集了临床信息,并对受影响最大的18个基因进行了基因测序分析。根据2016年和2021年世界卫生组织对中枢神经系统肿瘤的分类,比较了胶质母细胞瘤患者和非胶质母细胞瘤患者认知功能的差异,以评估其分化对认知的影响。研究发现,年龄、肿瘤位置和胶质母细胞瘤对认知功能有显著差异。一些基因改变与认知能力有明显相关性。尤其是IDH、CIC和ATRX与多个认知领域呈正相关,而其他大多数基因则呈负相关。就大多数重点基因而言,基因改变数量少的患者往往具有更好的认知功能。我们的研究表明,除了年龄、组织学类型和肿瘤位置等临床特征外,分子特征在认知功能中也起着至关重要的作用。进一步研究肿瘤影响脑功能的机制有望提高胶质瘤患者的生活质量。这项研究强调了在管理胶质瘤患者时同时考虑临床和分子因素以改善认知结果的重要性。
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Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification

Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study is to investigate the relationship between preoperative cognitive function and clinical as well as molecular factors, firstly based on the new 2021 World Health Organization’s updated classification of central nervous system tumors. A total of 110 diffuse glioma patients enrolled underwent preoperative cognitive assessments using the Mini-Mental State Examination and Montreal Cognitive Assessment. Clinical information was collected from medical records, and gene sequencing was performed to analyze the 18 most influenced genes. The differences in cognitive function between patients with and without glioblastoma were compared under both the 2016 and 2021 WHO classification of tumors of the central nervous system to assess their effect of differentiation on cognition. The study found that age, tumor location, and glioblastoma had significant differences in cognitive function. Several genetic alterations were significantly correlated with cognition. Especially, IDH, CIC, and ATRX are positively correlated with several cognitive domains, while most other genes are negatively correlated. For most focused genes, patients with a low number of genetic alterations tended to have better cognitive function. Our study suggested that, in addition to clinical characteristics such as age, histological type, and tumor location, molecular characteristics play a crucial role in cognitive function. Further research into the mechanisms by which tumors affect brain function is expected to enhance the quality of life for glioma patients. This study highlights the importance of considering both clinical and molecular factors in the management of glioma patients to improve cognitive outcomes.

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来源期刊
Journal of Molecular Neuroscience
Journal of Molecular Neuroscience 医学-神经科学
CiteScore
6.60
自引率
3.20%
发文量
142
审稿时长
1 months
期刊介绍: The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system. The criteria for acceptance of manuscripts will be scientific excellence, originality, and relevance to the field of molecular neuroscience. Manuscripts with clinical relevance are especially encouraged since the journal seeks to provide a means for accelerating the progression of basic research findings toward clinical utilization. All experiments described in the Journal of Molecular Neuroscience that involve the use of animal or human subjects must have been approved by the appropriate institutional review committee and conform to accepted ethical standards.
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