胆汁酸的生物活性、机制、生产以及在预防和治疗传染病中的潜在应用

IF 10.1 1区 工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY Engineering Pub Date : 2024-07-01 DOI:10.1016/j.eng.2023.11.017
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引用次数: 0

摘要

传染病是一个全球性的公共卫生问题,新发和复发的传染病在全球范围内呈上升趋势。因此,预防和治疗传染病仍然是一项重大挑战。胆汁酸是宿主和微生物体内常见的代谢产物,在控制脂质、葡萄糖和能量代谢方面发挥着重要作用。胆汁酸历来被用作相关代谢和肝胆疾病的一线重要治疗药物。值得注意的是,胆汁酸是牛黄和熊胆的主要有效成分,而牛黄和熊胆是常用的传统中药,具有清热解毒、疏风解痉的疗效。近年来,胆汁酸对传染性疾病的良好疗效引起了科学界的关注。本文首次综述了胆汁酸在治疗和预防传染病方面的生物活性、可能机制、生产途径和潜在应用。与以往的综述相比,我们全面总结了现有关于利用胆汁酸防治由病原微生物引起的传染病的研究,这些病原微生物是导致全球发病率和死亡率的主要原因。此外,为了确保以可承受的价格稳定供应胆汁酸,有必要阐明胆汁酸的生物合成,这将有助于科学家阐明胆汁酸的积累,并发现如何通过化学合成、生物合成和化学合成等手段来设计各种胆汁酸。最后,我们探讨了该领域目前面临的挑战,并就胆汁酸类药物的开发战略和胆汁酸的可持续生产提出了建议。这些研究表明,胆汁酸是一种潜在的新型治疗药物,可用于治疗传染性疾病,并能以可持续的方式进行人工合成。
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Bioactivities, Mechanisms, Production, and Potential Application of Bile Acids in Preventing and Treating Infectious Diseases

Infectious diseases are a global public health problem, with emerging and re-emerging infectious diseases on the rise worldwide. Therefore, their prevention and treatment are still major challenges. Bile acids are common metabolites in both hosts and microorganisms that play a significant role in controlling the metabolism of lipids, glucose, and energy. Bile acids have historically been utilized as first-line, valuable therapeutic agents for related metabolic and hepatobiliary diseases. Notably, bile acids are the major active ingredients of cow bezoar and bear bile, which are commonly used traditional Chinese medicines (TCMs) with the therapeutic effects of clearing heat, detoxification, and relieving wind and spasm. In recent years, the promising performance of bile acids against infectious diseases has attracted attention from the scientific community. This paper reviews for the first time the biological activities, possible mechanisms, production routes, and potential applications of bile acids in the treatment and prevention of infectious diseases. Compared with previous reviews, we comprehensively summarize existing studies on the use of bile acids against infectious diseases caused by pathogenic microorganisms that are leading causes of global morbidity and mortality. In addition, to ensure a stable supply of bile acids at affordable prices, it is necessary to clarify the biosynthesis of bile acids in vivo, which will assist scientists in elucidating the accumulation of bile acids and discovering how to engineer various bile acids by means of chemosynthesis, biosynthesis, and chemoenzymatic synthesis. Finally, we explore the current challenges in the field and recommend a development strategy for bile-acid-based drugs and the sustainable production of bile acids. The presented studies suggest that bile acids are potential novel therapeutic agents for managing infectious diseases and can be artificially synthesized in a sustainable way.

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来源期刊
Engineering
Engineering Environmental Science-Environmental Engineering
自引率
1.60%
发文量
335
审稿时长
35 days
期刊介绍: Engineering, an international open-access journal initiated by the Chinese Academy of Engineering (CAE) in 2015, serves as a distinguished platform for disseminating cutting-edge advancements in engineering R&D, sharing major research outputs, and highlighting key achievements worldwide. The journal's objectives encompass reporting progress in engineering science, fostering discussions on hot topics, addressing areas of interest, challenges, and prospects in engineering development, while considering human and environmental well-being and ethics in engineering. It aims to inspire breakthroughs and innovations with profound economic and social significance, propelling them to advanced international standards and transforming them into a new productive force. Ultimately, this endeavor seeks to bring about positive changes globally, benefit humanity, and shape a new future.
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