利用-组学技术和运动分子医学推进癌症恶病质诊断

IF 2.3 Q2 SPORT SCIENCES Sports Medicine and Health Science Pub Date : 2024-03-01 DOI:10.1016/j.smhs.2024.01.006
Stuart J. Hesketh
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引用次数: 0

摘要

肌肉萎缩会加重疾病的后果并增加死亡率,而保持骨骼肌的质量和功能对确保长期健康和整体生活质量起着关键作用。肌肉萎缩是一项重大的临床挑战,涉及肌肉质量和力量的持续丧失,常常伴随着多种癌症的发生。癌症恶病质是一种多因素综合征,发病率很高,虽然恶病质是癌症相关死亡的主要原因之一,但目前仍没有针对这种疾病的有效治疗策略。癌症恶病质的病因是全身炎症因子上调和分解代谢刺激,导致蛋白质合成受抑制,蛋白质降解增强。许多必要的细胞过程都会被恶病质破坏,从而介导细胞内信号通路,导致肌肉和细胞器的净损失。然而,人们对如何协调这些变化的分子机制还不完全了解。虽然仍有许多工作要做,但有组织的运动有能力抵消与癌症恶病质相关的许多不利影响。主要是通过刺激肌肉蛋白质合成、增强线粒体功能和释放肌动素。因此,肌肉质量和力量会增加,从而改善活动能力和生活质量。本综述总结了调控癌症恶病质和运动的复杂分子网络的现有知识,强调了两者之间的分子相互作用,以便进行潜在的治疗干预。最后,还考虑了基于质谱的蛋白质组学作为建立恶病质患者早期诊断生物标志物的一种方法的实用性。
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Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine

Muscle atrophy exacerbates disease outcomes and increases mortality, whereas the preservation of skeletal muscle mass and function play pivotal roles in ensuring long-term health and overall quality-of-life. Muscle atrophy represents a significant clinical challenge, involving the continued loss of muscle mass and strength, which frequently accompany the development of numerous types of cancer. Cancer cachexia is a highly prevalent multifactorial syndrome, and although cachexia is one of the main causes of cancer-related deaths, there are still no approved management strategies for the disease. The etiology of this condition is based on the upregulation of systemic inflammation factors and catabolic stimuli, resulting in the inhibition of protein synthesis and enhancement of protein degradation. Numerous necessary cellular processes are disrupted by cachectic pathology, which mediate intracellular signalling pathways resulting in the net loss of muscle and organelles. However, the exact underpinning molecular mechanisms of how these changes are orchestrated are incompletely understood. Much work is still required, but structured exercise has the capacity to counteract numerous detrimental effects linked to cancer cachexia. Primarily through the stimulation of muscle protein synthesis, enhancement of mitochondrial function, and the release of myokines. As a result, muscle mass and strength increase, leading to improved mobility, and quality-of-life. This review summarises existing knowledge of the complex molecular networks that regulate cancer cachexia and exercise, highlighting the molecular interplay between the two for potential therapeutic intervention. Finally, the utility of mass spectrometry-based proteomics is considered as a way of establishing early diagnostic biomarkers of cachectic patients.

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来源期刊
Sports Medicine and Health Science
Sports Medicine and Health Science Health Professions-Physical Therapy, Sports Therapy and Rehabilitation
CiteScore
5.50
自引率
0.00%
发文量
36
审稿时长
55 days
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