脂肪组织中的组蛋白甲基转移酶 SMYD1 受热刺激诱导。

IF 2.6 4区医学 Q2 GENETICS & HEREDITY Epigenomics Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI:10.2217/epi-2023-0381

Annunziata G Cicatiello, Annarita Nappi, Fabiana Franchini, Immacolata C Nettore, Maddalena Raia, Carmine Rocca, Tommaso Angelone, Monica Dentice, Paola Ungaro, Paolo E Macchia

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引用次数: 0

摘要

目的：研究组蛋白甲基转移酶 SMYD1 在白色脂肪组织（WAT）和棕色脂肪组织中的表达，以及前脂肪细胞向白色和米色表型分化过程中的表达。研究方法使用高脂饮食（并暴露于寒冷环境）的 C57BL/6J 小鼠和刺激分化为白色和米色脂肪细胞的 3T3-L1 细胞。结果SMYD1在以高脂饮食喂养的小鼠的WAT和暴露于寒冷的小鼠的WAT和棕色脂肪组织中的表达增加，表明其在产热中的作用。SMYD1在米色脂肪细胞中的表达高于白色脂肪细胞，沉默SMYD1会导致线粒体含量和Pgc-1α表达的减少。结论这些数据表明，SMYD1 在脂肪组织的能量控制中发挥着新的积极调节作用。

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The histone methyltransferase SMYD1 is induced by thermogenic stimuli in adipose tissue.

Aim: To study the expression of histone methyltransferase SMYD1 in white adipose tissue (WAT) and brown adipose tissue and during differentiation of preadipocytes to white and beige phenotypes. Methods: C57BL/6J mice fed a high-fat diet (and exposed to cold) and 3T3-L1 cells stimulated to differentiate into white and beige adipocytes were used. Results: SMYD1 expression increased in WAT of high-fat diet fed mice and in WAT and brown adipose tissue of cold-exposed mice, suggesting its role in thermogenesis. SMYD1 expression was higher in beige adipocytes than in white adipocytes, and its silencing leads to a decrease in mitochondrial content and in Pgc-1α expression. Conclusion: These data suggest a novel role for SMYD1 as a positive regulator of energy control in adipose tissue.

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.