{"title":"姜黄素和/或黑麦草对绝经后骨质疏松症或骨质增生妇女骨密度和生活质量的影响","authors":"Farzaneh Usefian , Azizeh Farshbaf- Khalili , Mojgan Mirghafourvand , Majid Mobasseri , Sakineh Mohammad-Alizadeh-Charandabi","doi":"10.1016/j.aimed.2024.03.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to assess the effect of Curcumin and/or Nigella sativa on bone density parameters (primary outcome) and quality of life (secondary outcome) in postmenopausal women with primary osteoporosis or osteopenia.</p></div><div><h3>Design</h3><p>Randomized controlled trial with factorial design.</p></div><div><h3>Methods</h3><p>120 postmenopausal women aged 50–65 years with primary osteoporosis or osteopenia were equally randomized into four groups receiving daily capsules for six months; 1) nanomicellar Curcumin 80 mg, 2) Nigella sativa oil 1000 mg, 3) both, 4) placebo. All groups also received conventional treatments. In addition to the baseline assessment, bone mineral density (BMD), T-score, and Z-score were assessed at six months and quality of life (using the menopause-specific quality of life questionnaire) at two, four, and six months of the interventions.</p></div><div><h3>Results</h3><p>Five cases were lost to follow-up. No serious side events were reported. After the interventions, significant increases were observed in the femoral neck-BMD within all groups (p<0.01) as well as in the lumbar spine-BMD within the Nigella sativa and nanomicellar Curcumin-Nigella sativa groups (p<0.05). However, there was no statistically significant difference between the groups in terms of bone density parameters and overall quality of life score. In the Curcumin group, vasomotor dimension (adjusted difference −0.90, 95% CI: −1.62 to −0.18) and in the Nigella, sativa group vasomotor (-0.76, −1.50 to −0.03) and physical (-0.61, −1.09 to −0.14) dimensions of quality of life score were significantly better than the placebo group.</p></div><div><h3>Conclusions</h3><p>The addition of Curcumin, Nigella sativa oil, or their combination does not significantly improve bone density parameters and overall quality of life of postmenopausal women with primary osteoporosis or osteopenia compared to routine treatment, but it can improve vasomotor function of quality of life. We suggest conducting long-term interventions based on the results.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Curcumin and/or Nigella sativa on bone density and quality of life in postmenopausal women with osteoporosis or osteopenia\",\"authors\":\"Farzaneh Usefian , Azizeh Farshbaf- Khalili , Mojgan Mirghafourvand , Majid Mobasseri , Sakineh Mohammad-Alizadeh-Charandabi\",\"doi\":\"10.1016/j.aimed.2024.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>This study aimed to assess the effect of Curcumin and/or Nigella sativa on bone density parameters (primary outcome) and quality of life (secondary outcome) in postmenopausal women with primary osteoporosis or osteopenia.</p></div><div><h3>Design</h3><p>Randomized controlled trial with factorial design.</p></div><div><h3>Methods</h3><p>120 postmenopausal women aged 50–65 years with primary osteoporosis or osteopenia were equally randomized into four groups receiving daily capsules for six months; 1) nanomicellar Curcumin 80 mg, 2) Nigella sativa oil 1000 mg, 3) both, 4) placebo. All groups also received conventional treatments. In addition to the baseline assessment, bone mineral density (BMD), T-score, and Z-score were assessed at six months and quality of life (using the menopause-specific quality of life questionnaire) at two, four, and six months of the interventions.</p></div><div><h3>Results</h3><p>Five cases were lost to follow-up. No serious side events were reported. After the interventions, significant increases were observed in the femoral neck-BMD within all groups (p<0.01) as well as in the lumbar spine-BMD within the Nigella sativa and nanomicellar Curcumin-Nigella sativa groups (p<0.05). However, there was no statistically significant difference between the groups in terms of bone density parameters and overall quality of life score. In the Curcumin group, vasomotor dimension (adjusted difference −0.90, 95% CI: −1.62 to −0.18) and in the Nigella, sativa group vasomotor (-0.76, −1.50 to −0.03) and physical (-0.61, −1.09 to −0.14) dimensions of quality of life score were significantly better than the placebo group.</p></div><div><h3>Conclusions</h3><p>The addition of Curcumin, Nigella sativa oil, or their combination does not significantly improve bone density parameters and overall quality of life of postmenopausal women with primary osteoporosis or osteopenia compared to routine treatment, but it can improve vasomotor function of quality of life. We suggest conducting long-term interventions based on the results.</p></div>\",\"PeriodicalId\":7343,\"journal\":{\"name\":\"Advances in integrative medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in integrative medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212958824000284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in integrative medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212958824000284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Effect of Curcumin and/or Nigella sativa on bone density and quality of life in postmenopausal women with osteoporosis or osteopenia
Objectives
This study aimed to assess the effect of Curcumin and/or Nigella sativa on bone density parameters (primary outcome) and quality of life (secondary outcome) in postmenopausal women with primary osteoporosis or osteopenia.
Design
Randomized controlled trial with factorial design.
Methods
120 postmenopausal women aged 50–65 years with primary osteoporosis or osteopenia were equally randomized into four groups receiving daily capsules for six months; 1) nanomicellar Curcumin 80 mg, 2) Nigella sativa oil 1000 mg, 3) both, 4) placebo. All groups also received conventional treatments. In addition to the baseline assessment, bone mineral density (BMD), T-score, and Z-score were assessed at six months and quality of life (using the menopause-specific quality of life questionnaire) at two, four, and six months of the interventions.
Results
Five cases were lost to follow-up. No serious side events were reported. After the interventions, significant increases were observed in the femoral neck-BMD within all groups (p<0.01) as well as in the lumbar spine-BMD within the Nigella sativa and nanomicellar Curcumin-Nigella sativa groups (p<0.05). However, there was no statistically significant difference between the groups in terms of bone density parameters and overall quality of life score. In the Curcumin group, vasomotor dimension (adjusted difference −0.90, 95% CI: −1.62 to −0.18) and in the Nigella, sativa group vasomotor (-0.76, −1.50 to −0.03) and physical (-0.61, −1.09 to −0.14) dimensions of quality of life score were significantly better than the placebo group.
Conclusions
The addition of Curcumin, Nigella sativa oil, or their combination does not significantly improve bone density parameters and overall quality of life of postmenopausal women with primary osteoporosis or osteopenia compared to routine treatment, but it can improve vasomotor function of quality of life. We suggest conducting long-term interventions based on the results.
期刊介绍：
Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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