用于组织工程的微流体电喷雾仿红细胞颗粒

IF 10.1 1区 工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY Engineering Pub Date : 2024-09-01 DOI:10.1016/j.eng.2023.08.022
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引用次数: 0

摘要

微粒已被证明具有再生医学的价值。这一领域的尝试往往集中在开发用于组织再生的智能多功能微粒上。受红细胞在受损组织中自我修复过程的启发,我们在此提出了新型仿生红细胞样微颗粒(ELMPs)。这些 ELMPs 由细胞外基质类混合水凝胶以及黑磷、血红蛋白和生长因子(GFs)等功能添加剂组成,通过微流体电喷雾技术生成。由于生成的 ELMPs 具有氧气输送能力,并能近红外响应地释放 GFs 和氧气,因此在作为微支架用于细胞粘附、刺激血管生成和调整货物释放轮廓时,它们将具有出色的生物相容性和多功能性能。基于这些特点,我们证明了 ELMPs 可以稳定地重叠填充伤口,并实现可控的货物释放,从而达到理想的组织再生治疗效果。因此,我们认为具有盘状形态和货物释放能力的生物仿生 ELMPs 是组织工程的理想选择。
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Biomimetic Erythrocyte-Like Particles from Microfluidic Electrospray for Tissue Engineering

Microparticles have demonstrated value for regenerative medicine. Attempts in this field tend to focus on the development of intelligent multifunctional microparticles for tissue regeneration. Here, inspired by erythrocytes-associated self-repairing process in damaged tissue, we present novel biomimetic erythrocyte-like microparticles (ELMPs). These ELMPs, which are composed of extracellular matrix-like hybrid hydrogels and the functional additives of black phosphorus, hemoglobin, and growth factors (GFs), are generated by using a microfluidic electrospray. As the resultant ELMPs have the capacity for oxygen delivery and near-infrared-responsive release of both GFs and oxygen, they would have excellent biocompatibility and multifunctional performance when serving as microscaffolds for cell adhesion, stimulating angiogenesis, and adjusting the release profile of cargoes. Based on these features, we demonstrate that the ELMPs can stably overlap to fill a wound and realize controllable cargo release to achieve the desired curative effect of tissue regeneration. Thus, we consider our biomimetic ELMPs with discoid morphology and cargo-delivery capacity to be ideal for tissue engineering.

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来源期刊
Engineering
Engineering Environmental Science-Environmental Engineering
自引率
1.60%
发文量
335
审稿时长
35 days
期刊介绍: Engineering, an international open-access journal initiated by the Chinese Academy of Engineering (CAE) in 2015, serves as a distinguished platform for disseminating cutting-edge advancements in engineering R&D, sharing major research outputs, and highlighting key achievements worldwide. The journal's objectives encompass reporting progress in engineering science, fostering discussions on hot topics, addressing areas of interest, challenges, and prospects in engineering development, while considering human and environmental well-being and ethics in engineering. It aims to inspire breakthroughs and innovations with profound economic and social significance, propelling them to advanced international standards and transforming them into a new productive force. Ultimately, this endeavor seeks to bring about positive changes globally, benefit humanity, and shape a new future.
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