{"title":"分析饱和发病率和治疗率对 COVID-19 根除效果影响的新型数学模型和同调扰动法","authors":"Ajimot Folashade Adebisi, Morufu Oyedunsi Olayiwola, Ibrahim Adeshola Adediran, Adedapo Ismaila Alaje","doi":"10.1007/s40995-024-01608-w","DOIUrl":null,"url":null,"abstract":"<div><p>Saturated incidence rates and treatment responses are essential in epidemiology and clinical research. They signify peak event occurrences in a population, aiding in disease understanding and intervention planning. This study proposes a mathematical model of COVID-19, focusing on the impact of saturated incidence rates and treatment responses on its dynamical transmission. Via qualitative analysis, the existence and uniqueness of the model’s solution are verified, a positive invariant region is established, and the local stability analysis highlights the model’s resilience to minor perturbations. The model solution is obtained utilizing the homotopy perturbation method, and simulations with Maple 18 software reveal that increasing treatment intensity might not result in significant additional decrease in the number of infections, particularly in situations where the spread of infection is uncontrolled. Thus, the finding underscores the need to refine treatment strategies through a tailored approach and to optimize preventive measures.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 3","pages":"625 - 636"},"PeriodicalIF":1.4000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Novel Mathematical Model and Homotopy Perturbation Method Analyzing the Effects of Saturated Incidence and Treatment Rate on COVID-19 Eradication\",\"authors\":\"Ajimot Folashade Adebisi, Morufu Oyedunsi Olayiwola, Ibrahim Adeshola Adediran, Adedapo Ismaila Alaje\",\"doi\":\"10.1007/s40995-024-01608-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Saturated incidence rates and treatment responses are essential in epidemiology and clinical research. They signify peak event occurrences in a population, aiding in disease understanding and intervention planning. This study proposes a mathematical model of COVID-19, focusing on the impact of saturated incidence rates and treatment responses on its dynamical transmission. Via qualitative analysis, the existence and uniqueness of the model’s solution are verified, a positive invariant region is established, and the local stability analysis highlights the model’s resilience to minor perturbations. The model solution is obtained utilizing the homotopy perturbation method, and simulations with Maple 18 software reveal that increasing treatment intensity might not result in significant additional decrease in the number of infections, particularly in situations where the spread of infection is uncontrolled. Thus, the finding underscores the need to refine treatment strategies through a tailored approach and to optimize preventive measures.</p></div>\",\"PeriodicalId\":600,\"journal\":{\"name\":\"Iranian Journal of Science and Technology, Transactions A: Science\",\"volume\":\"48 3\",\"pages\":\"625 - 636\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Science and Technology, Transactions A: Science\",\"FirstCategoryId\":\"4\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40995-024-01608-w\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Science and Technology, Transactions A: Science","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1007/s40995-024-01608-w","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
饱和发病率和治疗反应在流行病学和临床研究中至关重要。它们标志着人群中出现的峰值事件,有助于了解疾病和制定干预计划。本研究提出了 COVID-19 的数学模型,重点研究饱和发病率和治疗反应对其动态传播的影响。通过定性分析,验证了模型解的存在性和唯一性,建立了正不变量区域,局部稳定性分析强调了模型对微小扰动的弹性。利用同调扰动法获得了模型解,并使用 Maple 18 软件进行了模拟,结果表明,增加治疗强度可能不会导致感染数量的显著额外减少,尤其是在感染传播不受控制的情况下。因此,这一发现突出表明,有必要通过量身定制的方法完善治疗策略,并优化预防措施。
A Novel Mathematical Model and Homotopy Perturbation Method Analyzing the Effects of Saturated Incidence and Treatment Rate on COVID-19 Eradication
Saturated incidence rates and treatment responses are essential in epidemiology and clinical research. They signify peak event occurrences in a population, aiding in disease understanding and intervention planning. This study proposes a mathematical model of COVID-19, focusing on the impact of saturated incidence rates and treatment responses on its dynamical transmission. Via qualitative analysis, the existence and uniqueness of the model’s solution are verified, a positive invariant region is established, and the local stability analysis highlights the model’s resilience to minor perturbations. The model solution is obtained utilizing the homotopy perturbation method, and simulations with Maple 18 software reveal that increasing treatment intensity might not result in significant additional decrease in the number of infections, particularly in situations where the spread of infection is uncontrolled. Thus, the finding underscores the need to refine treatment strategies through a tailored approach and to optimize preventive measures.
期刊介绍:
The aim of this journal is to foster the growth of scientific research among Iranian scientists and to provide a medium which brings the fruits of their research to the attention of the world’s scientific community. The journal publishes original research findings – which may be theoretical, experimental or both - reviews, techniques, and comments spanning all subjects in the field of basic sciences, including Physics, Chemistry, Mathematics, Statistics, Biology and Earth Sciences