Yan Zhang M.D. , Fang Fang M.D. , Lijuan Xi M.D. , Jiajie Zhou M.D. , Peirong Xu M.D. , Jiayuan Tu M.D.
{"title":"血红蛋白-红细胞分布宽度比与认知能力的关系：横断面研究","authors":"Yan Zhang M.D. , Fang Fang M.D. , Lijuan Xi M.D. , Jiajie Zhou M.D. , Peirong Xu M.D. , Jiayuan Tu M.D.","doi":"10.1016/j.aggp.2024.100027","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to investigate the association between hemoglobin-to-red blood cell distribution width ratio (HRR) and cognitive function.</p></div><div><h3>Methods</h3><p>Data, including cognition assessment, general characteristics, lifestyle attributes, disease-related factors, and blood indicators, were extracted from older people from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 database. Statistical analysis included the Mann-Whitney <em>U</em> test, chi-square test, spearman correlation, and multiple linear regression.</p></div><div><h3>Results</h3><p>A total of 2452 participants were included, with 631(25.7 %) identified as having low-level cognition. HRR was significantly lower in the lower cognition group (<em>P</em> < 0.001) and positively associated with cognition score (<em>P</em> < 0.001). Multiple linear logistic regression analysis indicated that HRR remained associated with cognition even after adjusting for general characteristics, lifestyle attributes, disease-related factors, and blood indicators (<em>P</em> = 0.046).</p></div><div><h3>Conclusion</h3><p>Lower HRR is an independent risk factor for low cognitive performance in older adults. However, further investigation is needed to elucidate the precise mechanism underlying the impact of HRR on cognitive function.</p></div>","PeriodicalId":100119,"journal":{"name":"Archives of Gerontology and Geriatrics Plus","volume":"1 3","pages":"Article 100027"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950307824000249/pdfft?md5=7263d1340d805026207b759e6827f52f&pid=1-s2.0-S2950307824000249-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Association of hemoglobin-to-red blood cell distribution width ratio and cognition: A cross-sectional study\",\"authors\":\"Yan Zhang M.D. , Fang Fang M.D. , Lijuan Xi M.D. , Jiajie Zhou M.D. , Peirong Xu M.D. , Jiayuan Tu M.D.\",\"doi\":\"10.1016/j.aggp.2024.100027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>This study aimed to investigate the association between hemoglobin-to-red blood cell distribution width ratio (HRR) and cognitive function.</p></div><div><h3>Methods</h3><p>Data, including cognition assessment, general characteristics, lifestyle attributes, disease-related factors, and blood indicators, were extracted from older people from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 database. Statistical analysis included the Mann-Whitney <em>U</em> test, chi-square test, spearman correlation, and multiple linear regression.</p></div><div><h3>Results</h3><p>A total of 2452 participants were included, with 631(25.7 %) identified as having low-level cognition. HRR was significantly lower in the lower cognition group (<em>P</em> < 0.001) and positively associated with cognition score (<em>P</em> < 0.001). Multiple linear logistic regression analysis indicated that HRR remained associated with cognition even after adjusting for general characteristics, lifestyle attributes, disease-related factors, and blood indicators (<em>P</em> = 0.046).</p></div><div><h3>Conclusion</h3><p>Lower HRR is an independent risk factor for low cognitive performance in older adults. However, further investigation is needed to elucidate the precise mechanism underlying the impact of HRR on cognitive function.</p></div>\",\"PeriodicalId\":100119,\"journal\":{\"name\":\"Archives of Gerontology and Geriatrics Plus\",\"volume\":\"1 3\",\"pages\":\"Article 100027\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2950307824000249/pdfft?md5=7263d1340d805026207b759e6827f52f&pid=1-s2.0-S2950307824000249-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Gerontology and Geriatrics Plus\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950307824000249\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Gerontology and Geriatrics Plus","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950307824000249","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association of hemoglobin-to-red blood cell distribution width ratio and cognition: A cross-sectional study
Purpose
This study aimed to investigate the association between hemoglobin-to-red blood cell distribution width ratio (HRR) and cognitive function.
Methods
Data, including cognition assessment, general characteristics, lifestyle attributes, disease-related factors, and blood indicators, were extracted from older people from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 database. Statistical analysis included the Mann-Whitney U test, chi-square test, spearman correlation, and multiple linear regression.
Results
A total of 2452 participants were included, with 631(25.7 %) identified as having low-level cognition. HRR was significantly lower in the lower cognition group (P < 0.001) and positively associated with cognition score (P < 0.001). Multiple linear logistic regression analysis indicated that HRR remained associated with cognition even after adjusting for general characteristics, lifestyle attributes, disease-related factors, and blood indicators (P = 0.046).
Conclusion
Lower HRR is an independent risk factor for low cognitive performance in older adults. However, further investigation is needed to elucidate the precise mechanism underlying the impact of HRR on cognitive function.
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