伴有听觉言语幻觉的精神分裂症患者的颞上沟凹陷。

IF 3.1 Q2 NEUROSCIENCES AIMS Neuroscience Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI:10.3934/Neuroscience.2024002
Baptiste Lerosier, Gregory Simon, Sylvain Takerkart, Guillaume Auzias, Sonia Dollfus
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引用次数: 0

摘要

幻听(AVH)是精神分裂症最常见的致残性症状之一。它们涉及与语言处理相关的颞上沟(STS);STS的特定模式可能反映出精神分裂症患者对幻听的易感性。STS 沟坑是该区域褶皱的最深点,本文将其作为 AVHs 的解剖学标志进行研究。这项研究包括 53 名被诊断为精神分裂症且过去或现在患有 AVH 的患者,以及 100 名健康对照志愿者。所有参与者都接受了 3-T 磁共振成像 T1 脑扫描,并比较了两组患者脑沟凹陷的差异。与对照组相比,AVHs 患者左侧 STS 沟坑数量的分布明显不同,表明其形态模式并不复杂。STS沟槽形态与AVH的关联表明,精神分裂症伴AVH的病理生理学中存在一个早期神经发育过程。
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Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.

Auditory verbal hallucinations (AVHs) are among the most common and disabling symptoms of schizophrenia. They involve the superior temporal sulcus (STS), which is associated with language processing; specific STS patterns may reflect vulnerability to auditory hallucinations in schizophrenia. STS sulcal pits are the deepest points of the folds in this region and were investigated here as an anatomical landmark of AVHs. This study included 53 patients diagnosed with schizophrenia and past or present AVHs, as well as 100 healthy control volunteers. All participants underwent a 3-T magnetic resonance imaging T1 brain scan, and sulcal pit differences were compared between the two groups. Compared with controls, patients with AVHs had a significantly different distributions for the number of sulcal pits in the left STS, indicating a less complex morphological pattern. The association of STS sulcal morphology with AVH suggests an early neurodevelopmental process in the pathophysiology of schizophrenia with AVHs.

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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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